PHCbi-Panasonic eBook - 21

Cell Therapy Today * New Developments in Immunotherapy * The Cleanroom Alternative to CAR T-Cell Therapy and Regenerative Medicine Facilities

tories without a need for expensive structural
changes, remodeling, renovating, or construction. This is particularly beneficial to companies
marketing highly specific products focused on
narrow applications.
2. The work station does not require a dedicated
staff. Upkeep, standard operating procedures,
compliance criteria, and maintenance are straightforward and easier to delegate to existing staff.
3. Inconveniences associated with cleanroom
access are eliminated. There is no need to gown,
and workers can manage daily activities with
flexibility to come and go as desired, from lunch
to bathroom breaks, without compromising the
Class 100 environment.
4. Aside from the benefits of proximity and integrated operation, the amortized costs of a cell
processing work station are significantly less
than those of a cleanroom, both in terms of labor,
on-demand operation, throughput, and cost of

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laboratory space, often millions of dollars less.
5. The integrated design of the cell processing
work station contains essential systems required
for most protocols, from cell culture management,
assessment, and incubation.
6. Utilities in the work station can be turned
off when the system is not in service, whereby
a cleanroom must operate continuously. At
the beginning of the day, the work station
requires less than 90 minutes to reach operating
parameters.
7. There is no potential for cross-contamination
between patient samples. Decontamination
between patient processes physically separates
individuals, permitting a single work station to
service many patients with higher throughput.
8. For production applications, transition to FDA
compliance protocols is easier, as the work station
helps centralize and standardize your procedures

and remove unknown variables inherent to a
non-closed loop solution.

Cell Processing Work Station Attributes
and Benefits
The cell processing work station eliminates
the need for a cleanroom. The work station
is multi-functional, sharable, and expands
options for installation. It is ergonomically
designed to improve comfort. Ultimately, it
increases throughput in facilities where the
needs of multiple patients or researchers must
be accommodated. It is ideal for laboratories
managing simultaneous projects that require
cGMP-compliant conditions. Changeover from
one researcher to another with complete decontamination takes a matter of hours. All of this
is tracked, logged, and part of your clear and
defined process flow.
At the heart of the system is a unique mobile
incubator design, fully functional for both CO2

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PHCbi-Panasonic eBook

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