PHCbi-Panasonic eBook - 30

Local Immunotherapy
Shrinks Tumors Near and Far
I

In situ vaccination was developed by Stanford
University scientists who believe that their
approach, which involves local application of
tiny amounts of immunoenhancing agents,
could serve as a rapid and relatively inexpensive cancer therapy. These agents? An innate
30

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immune system activator called CpG, and a
stimulatory antibody called anti-OX40.
The scientists, led by oncologist Ronald
Levy, M.D., also emphasize that their
approach is unlikely to cause the adverse
side effects often seen with body-wide
immune stimulation.
"When we use these two agents together, we
see the elimination of tumors all over the body,"
said Dr. Levy. "This approach bypasses the need
to identify tumor-specific immune targets and
doesn't require wholesale activation of the
immune system or customization of a patient's
immune cells."

ADDITIONAL CONTENT

Podcast
Control the hypoxia condition of in situ
transplantation cell culturing in tumor biology.
PHC Business Intelligence and Product Manager
discusses the significance of O2 control for
reproducibility.
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KATERYNA KON/Science Photo Library/Getty Images

nject locally, treat globally. That's the gist
of a new cancer immunotherapy strategy
called in situ vaccination. It has three steps: (1)
Deliver immunoenhancing agents to a tumor
site. (2) Trigger an immune response among
"prescreened" T cells, that is, T cells that have
already shown that they can infiltrate the
tumor. (3) Watch the T cells attack cancer
throughout the body.

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