Sartorius #2 eBook - 2019 - 11

DRUG DISCOVERY

Bispecific Playgrounds?
No, Factory Floors

Developers Prepare for Future Biologics Work by
Exploring a Multitude of Antibody Formats

Patricia Fitzpatrick Dimond

ispecific antibodies (bsAbs) represent a relatively new and clinically validated class
of therapeutic molecules. Three bsAbs have been approved for different therapeutic
indications, and over 50 bsAbs are currently in clinical development.

Scientists have been particularly inventive in creating solutions to the fundamental
problem of combining two antibody specificities into one molecule, with protein engineering playing a significant role in bsAb development. So many solutions have been
devised that therapeutic developers may choose from a vast array of bsAb formats.
Different bsAb formats have distinct characteristics and support unique modes of action.
When choosing or working within bsAb formats, developers must consider how these
formats will influence factors such as biology and therapeutic activity. Other factors that
must be considered are developability, manufacturability, and stability. All these factors
influence the progression of bsAbs to the clinic.
Exploring the Format Playground

Patricia Fitzpatrick Dimond, PhD, is
technical editor of Clinical OMICs and
president of BioInsight Communications.
11 |

GENengnews.com

Since Genentech's development of the fundamentally enabling knobs-into-holes technology for producing immunoglobulin G (IgG)-like bsAbs, methods for building these
molecules have proliferated in a highly competitive environment in pharma and biotech
companies, creating a "technological playground," in the estimation of some investigators.
The diversity of bsAb formats has also been called a "zoo."

Infographic: Challenges and
Solutions for Developing
New Monoclonal Antibodies

https://www.sartorius.com/en/pr/mab/challenges-and-solutions-for-developing-new-monoclonal-antibodies?utm_source=gen&utm_medium=extbanner&utm_campaign=mabdevinoncology&utm_term=2019_ebook&mrksrc=thirdparty&utm_content=infographic http://www.GENengnews.com

Sartorius #2 eBook - 2019

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