Sartorius #2 eBook - 2019 - 20

DRUG DISCOVERY

New Methods Improve
Ab Engineering

Developers Work to Discover First-in-Class Therapeutics

DeeAnn Visk Ph.D.

rug discovery and development companies are racing to bring antibody therapies to
market. Competition is fierce to be the first to win FDA approval for first-in-class
treatments, especially for cancer.

At the recent Antibody Engineering and Therapeutics conference in San Diego, CA, several
new research approaches were presented along with their application in drug development
and discovery.
Making therapeutic antibodies means that a living organism, usually a cell line, must
manufacture the antibody. Getting the cell lines to do this is generally accomplished by
transfection. One company coming up with techniques to shave time off the development
timelines for therapeutic antibodies is Maxcyte.
"We offer a platform that transfects cells using Flow Electroporation™ technology to
introduce molecules (protein, DNA, or RNA) into a large range of cells-1/2 million to 200
billion. No additional chemicals or viruses are required with the MaxCyte process," explains
James Brady, Ph.D., vice president of technical applications and customer support.
Another advantage of Maxcyte's systems, according to Dr. Brady, is the ability to generate
milligram to gram quantities of protein via transient expression.
DeeAnn Visk Ph.D., is founder and principal
writer, DeeAnn Visk Consulting
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GENengnews.com

"Going to the time and effort of creating stably transfected cells is not necessary when a
transient transfection can yield gram quantities of protein," he says. Systems developed by

Infographic: Challenges and
Solutions for Developing
New Monoclonal Antibodies

https://www.sartorius.com/en/pr/mab/challenges-and-solutions-for-developing-new-monoclonal-antibodies?utm_source=gen&utm_medium=extbanner&utm_campaign=mabdevinoncology&utm_term=2019_ebook&mrksrc=thirdparty&utm_content=infographic http://www.GENengnews.com

Sartorius #2 eBook - 2019

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