Sartorisu-Sowmya eBook - 19

DECIPHERING THE IMMUNE RESPONSE TO VIRAL INFECTION

Blood Clotting Patterns in Lungs of COVID-19 Patients
May Help Explain Apparent Differences in Mortality

A

19 | GENengnews.com

NIAID-RML

study in Ireland has found that some Caucasian
patients hospitalized with severe COVID-19 develop a
form of abnormal blood clotting that can contribute to
death. The study, carried out by clinician scientists at the Irish
Centre for Vascular Biology, RCSI, and St. James's Hospital,
Dublin, found that the abnormal blood clotting caused microclots within the lungs, and that patients with higher levels of
blood clotting activity had a significantly worse prognosis
and were more likely to require admission to an intensive care
unit (ICU). The investigators say their results may also help to
explain emerging evidence of differences in racial susceptible to
COVID-19 mortality.
The study is published in the British Journal of Haematology.
"Our novel findings demonstrate that COVID-19 is associated
with a unique type of blood clotting disorder that is primarily
focused within the lungs and which undoubtedly contributes to
the high levels of mortality being seen in patients with COVID19," said James O'Donnell, MD, director of the Irish Centre for
Vascular Biology, RCSI, and consultant hematologist at the
National Coagulation Centre in St James's Hospital, Dublin.

This scanning electron microscope image shows SARS-CoV-2 (yellow) also known
as 2019-nCoV, the virus that causes COVID-19 isolated from a patient in the United
States, emerging from the surface of cells (blue/pink) cultured in the lab.
ADDITIONAL CONTENT
Blog Article: In our fight against viral pneumonia,
the "Mighty Macrophage" packs a punch.

https://www.essenbioscience.com/en/about/decoding-cells-blog/viral-pneumonia-mighty-macrophage-packs-a-punch/ http://www.GENengnews.com

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