Sartorisu-Sowmya eBook - 23

DECIPHERING THE IMMUNE RESPONSE TO VIRAL INFECTION

Yuan Tian, La Jolla Institute for Immunology

I

n many episodes of Law & Order, prosecutors would uncover new
information that forced them to rethink their theory of the case.
Sometimes, they'd even drop all charges against their prime
suspect. Such a dramatic turn has occurred in an investigation
of dengue shock, a severe form of dengue fever. Dengue
shock has been thought to be incited by overactive CD4
T cells, but according to a review of transcriptional
signatures, CD4 T cells have been innocent all along.
"We found no evidence to support the common
dogma that these T cells are responsible for turning a
mild infection to a severe one," said Yuan Tian, PhD, an
immunology fellow and bioinformatics student at La Jolla
Institute for Immunology (LJI). "This will help us narrow the
search for the true culprit."
Tian was on an investigative team led by Alessandro
Sette, Dr. Biol. Sci., a professor of vaccine discovery at LJI, and
Daniela Weiskopf, PhD, an instructor at LJI. The team's goal was
to define the molecular pattern of dengue-specific CD4 T cells
and to investigate whether there is a difference in the T-cell response

23 | GENengnews.com

ADDITIONAL CONTENT
Application Note: A Kinase Inhibitor Phenotypic
Screen Using A Multiplex T Cell Activation Assay

Laguna Design / Getty Images

Dengue Shock Investigation
Clears CD4 T Cells of Wrongdoing

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