Sartorisu-Sowmya eBook - 7

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DECIPHERING THE IMMUNE RESPONSE TO VIRAL INFECTION

kinetics of immune responses during a non-severe case of
COVID-19...We propose that these immune parameters
should be characterized in larger cohorts of people with
COVID-19 with different disease severities to determine
whether they could be used to predict disease outcome and
evaluate new interventions that might minimize severity and/
or to inform protective vaccine candidates."

7 | GENengnews.com

The patient was enrolled for testing through a coronavirus
substudy that is part of the Sentinel Travelers and Research
Preparedness for Emerging Infectious Disease (SETREP-ID)
initiative, which is led by Royal Melbourne Hospital Infectious
Diseases physician Irani Thevarajan, MD, at the Doherty
Institute. SETREP-ID is a platform that enables a broad range
of biological sampling to take place in returned travelers in the
event of a new and unexpected infectious disease outbreak,
which is exactly how COVID-19 started in Australia. "When
COVID-19 emerged, we already had ethics and protocols in
place so we could rapidly start looking at the virus and immune
system in great detail," Thevarajan said. "Already established
at a number of Melbourne hospitals, we now plan to roll out
SETREP-ID as a national study."
Thevarajan commented that according to current estimates
more than 80% of COVID-19 cases are mild-to-moderate,
and understanding the immune response in these mild cases
represents key research. "We hope to now expand our work
nationally and internationally to understand why some people
die from COVID-19, and build further knowledge to assist in
the rapid response of COVID-19 and future emerging viruses,"
she stated. n
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Sartorisu-Sowmya eBook

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