Sartorisu-Sowmya eBook - 8

DECIPHERING THE IMMUNE RESPONSE TO VIRAL INFECTION

Spying on the Viral Enemy
with Live-Cell Imaging and
Advanced Flow Cytometry
Jill Granger, M.S., Technical Writer, Essen Bioscience/Sartorius

T

8 | GENengnews.com

NIAD

he rapid emergence of the COVID-19 pandemic has
scientists working tirelessly with groundbreaking speed
to unravel disease pathology, immune responses, identify
therapeutics, and develop vaccines. Driving quickly toward
understanding these critical elements requires automated,
integrated analysis systems that capture key biological events to
generate new insights that guide experimental decision-making.
Any good battle plan begins with intelligence gathering
to learn the enemy's vulnerabilities, and viral infection is no
exception. Live-cell analysis and advanced high-throughput
flow cytometry are well-suited for this type of reconnaissance
mission and can be strategically incorporated into research
workflows to capture and analyze important biological events
in real time. This "spying on the enemy" approach can reveal
secrets of viral binding and entry into host cells, the "hi-jacking"
of host transcriptional machinery for replication, the interactions
between the host and immune system, and viral spreading.

Colorized scanning electron micrograph of an apoptotic cell (red) heavily infected
with SARS-COV-2 virus particles (yellow), isolated from a patient sample.
Image captured at the NIAID Integrated Research
Facility (IRF) in Fort Detrick, Maryland.

ADDITIONAL CONTENT
Whitepaper: Live-cell Immunocytochemistry
Correlating surface marker expression with
morphological and functional changes in
living cells over time

https://www.essenbioscience.com/en/forms/white-paper-live-cell-immunocytochemistry/ http://www.GENengnews.com

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