Unchained Labs eBook - 10

Protein
characterization
turned up to 11
There are many different tools, old and
new, for characterizing proteins. For
ranking and comparing the stability of
biologics and formulations, the most
established ones rely on temperature
stress to disrupt the 3D protein structure. These accelerated thermal ramp
measurements are good surrogates
for room-temperature stability and
for extrapolating to downstream
processes.

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GENengnews.com

With trends in biopharmaceuticals moving
towards high concentration solutions, thorough characterization is more important
than ever for reducing the risk of aggregation
and precipitation of the final product. If
biologics tend towards self-interaction,
high viscosity of the concentrated protein
solution is another risk. Determinations of
stability and aggregation propensity
earlier and on more candidate samples
or formulations can save time later.

Learn more
Get your screen on with Uncle
Uncle combines 3 different measurement
modes - fluorescence, SLS, and DLS.
With 11 different apps, Uncle will show you
more about your protein's stability with way
less sample than any other tool out there.

http://go.unchainedlabs.com/all-in-one-uncle http://GENengnews.com

Unchained Labs eBook

Table of Contents for the Digital Edition of Unchained Labs eBook