BQ Journal Vol 49 - Q4 2022 - 39

Caring for Young Women
Who Are at High Risk for
EARLY-ONSET
BREAST CANCER
A Summary of Screening, Counseling, and Testing Guidelines
Health care providers can play a critical role in helping to reduce the incidence of hereditary
breast and ovarian cancer by identifying patients with elevated risk. The following guidelines can
help identify young women who may have a higher risk for hereditary breast and ovarian cancer
and detect early-onset breast cancer among these women. The recommendations are based on
current peer-reviewed evidence for screening, counseling, and testing.
Who is at high risk for early-onset breast cancer?
According to the American Cancer Society (ACS), women who are at high risk for early-onset
breast cancer include those who:

Have a known BRCA1 or BRCA2 gene mutation.

Have a first-degree relative* (parent, brother, sister, or child), second-degree relative (aunts, uncles,
nieces, or grandparents), or third-degree relative, which includes first cousins, with a BRCA1 or BRCA2
gene mutation.

Have a lifetime risk of breast cancer of about 20% to 25% or greater, according to risk assessment tools
https://www.cdc.gov/cancer/breast/young_women/bringyourbrave/health_care_provider_education/
risk_assessment_tools.htm that are based mainly on family history.
 Had radiation therapy to the chest between the ages of 10 and 30 years.

Have Li-Fraumeni syndrome, Cowden syndrome, or Bannayan-Riley-Ruvalcaba syndrome, or have firstdegree
relatives with one of these syndromes.
What are the current genetic counseling and testing guidelines for
women at high risk for breast cancer?
The ACS recommends genetic testing for women at high risk, as defined above, to look for
mutations in the BRCA1 and BRCA2 genes (or less commonly in other genes such as PTEN or
*Risk is higher with more than one affected first-degree relative and if the affected relative was diagnosed at a young age.
Diagnostics I Pharmaceuticals I DxRx Solutions I Continuing Education I News
39
A Henry Schein Publication

https://www.cdc.gov/cancer/breast/young_women/bringyourbrave/health_care_provider_education/risk-assessment-management-strategies/risk-assessment.htm https://www.cdc.gov/cancer/breast/young_women/bringyourbrave/health_care_provider_education/risk-assessment-management-strategies/risk-assessment.htm

BQ Journal Vol 49 - Q4 2022

Table of Contents for the Digital Edition of BQ Journal Vol 49 - Q4 2022

Table of Contents
BQ Journal Vol 49 - Q4 2022 - Cover1
BQ Journal Vol 49 - Q4 2022 - 2
BQ Journal Vol 49 - Q4 2022 - Table of Contents
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BQ Journal Vol 49 - Q4 2022 - Cover4
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