IEEE Circuits and Systems Magazine - Q3 2022 - 35

Table II.
Parameters of the TESD.
Inter-ictal Period
Patients Gender Age
No.1
No.2
No.3
No.4
No.5
No.6
Average
Male
Male
Female
Male
Female
Male
34
23
26
46
31
22
Years
of RE
6
9
14
8
15
5
30.3 9.5
ACL
(µV) SCL
125
132
172
227
266
307
205
18.3
20.4
27.1
42.6
19.7
34.9
AS
(µV/ms)
2.8
3.1
3.5
4.8
4.9
4.1
27.2 3.9
the incision area. The reference electrode and the grounding
electrode (alligator clamp electrodes, BX-LY02-1500,
Greentek) were added to the ear and nose of the rat, respectively.
The scalp EEG signals in inter-ictal period were
recorded and fed to the WER. Further, a hole located at the
anterior fontanelle was drilled. Then, picrotoxin (PTX)
(0.2 µM/µL) was injected to the CA1 area using a microsyringe
of 50 µL through a 7G needle. The total injection
amount of PTX was 5 µL. When the epileptic seizure was
successfully induced, the scalp EEG signals in the ictal period
(which contains many spikes) were recorded.
Thirdly, a stimulating pulse was delivered to the vagus
nerve of the rodent to imitate electrical stimulation on human
subjects, and verify the stimulation effect of the IVNS.
During stimulation, two holes located at the left vagus nerve
were drilled, and two stimulating electrodes were passed
through the holes and positioned on the vagus nerve surface.
Then, an electrical pulse, with a repetition frequency
of 130 Hz, an intensity of 0.5 mA and a pulse width of 100 µs,
was applied on the stimulating electrodes. The stimulating
Ictal Period
ACL
(µV) SS
262
435
658
862
551
846
602
0.96
0.99
1.33
1.94
1.41
1.81
1.41
AS
(µV/ms)
5.8
6.4
7.7
12.3
8.3
11.6
8.7
k
3
3
4
4
2
3
3
d
2
2
2
3
2
3
THCL
(µV)
180
193
280
397
305
411
2 294
THS
(µV/ms)
4.7
5.1
6.3
10.6
7.7
9.5
7.3
Figure 16. Test of the WER.
Figure 17. Rodent epilepsy model preparation and setup.
THIRD QUARTER 2022
IEEE CIRCUITS AND SYSTEMS MAGAZINE
35

IEEE Circuits and Systems Magazine - Q3 2022

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