IEEE Solid-States Circuits Magazine - Fall 2020 - 42

and decoded to provide real-time
data. The miniaturized monitor, de--
monstrated in Figure 11, employs a
lead zirconate-titanate piezo and a
luminescence sensor that consists of
a μLED for optical excitation, a biocompatible O2-sensitive ruthenium
(Ru) luminescent sensor, and an in--
tegrated chip designed in a 65-nm,
low-power CMOS process. The system has been tested in an in vitro

0.18-μm, 5-V CMOS process, excites
the O2-sensing luminescent film
with a blue LED and measures the
resulting current flowing through
a photodiode. Figure 13 shows the
top-level block diagram. The readout IC consists of two power management blocks, an analog FE (AFE),
and an LED driver block. The system
has two identical power management blocks to isolate the power

experiment. The initial results show
promise. A comparison of the proposed O2 monitor and a commercial
O2 probe is given in Figure 12(c).

Noninvasive Transcutaneous
O2 Monitor

An integrated readout dedicated
for sensing the partial pressure of
transcutaneous O2 is presented in
[22]. The readout IC, designed in a

Spotlight

PD
LED

Wavelength
630 nm

(a)

(b)

Wavelength
800 nm

Lumee Oxygen

(c)

(d)

(e)

20
Baseline

Occlusion

Recovery

[O2] (µM)

15
10
5
0
-300

-200

-100
0
100
200
300
Time Relative to Start of Occlusions (s)

400

500

PtcO2 (mmHG)

100
80

Baseline

Occlusion

Recovery

60
40
20
0
-300

-200

-100
0
100
200
300
Time Relative to Start of Occlusions (s)
(f)

400

500

FIGURE 10:  The Profusa sensor system with (a) a hydrogel implantable sensor, (b) an injector device, (c) a console, and (d) a light source and
PD module. (e) A cross section showing the basic working principle. (f) Data showing the Profusa system detecting changes in the blood O2
status. Adapted from [48] and [49].

42	

FA L L 2 0 2 0	

IEEE SOLID-STATE CIRCUITS MAGAZINE	



IEEE Solid-States Circuits Magazine - Fall 2020

Table of Contents for the Digital Edition of IEEE Solid-States Circuits Magazine - Fall 2020

Contents
IEEE Solid-States Circuits Magazine - Fall 2020 - Cover1
IEEE Solid-States Circuits Magazine - Fall 2020 - Cover2
IEEE Solid-States Circuits Magazine - Fall 2020 - Contents
IEEE Solid-States Circuits Magazine - Fall 2020 - 2
IEEE Solid-States Circuits Magazine - Fall 2020 - 3
IEEE Solid-States Circuits Magazine - Fall 2020 - 4
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IEEE Solid-States Circuits Magazine - Fall 2020 - Cover3
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