Assay and Drug Development Technologies - 30

EGLEN AND RANDLE
adoption of 3D culture in many drug discovery organizations
indicates that these technologies have advantages, particularly
in oncology, but increasingly in neuroscience and
regenerative cell therapy.22 As 3D culture technologies, protocols,
and automation technologies continue to improve, and
the available range of human primary cells becomes ever
broader, drug discovery is indeed going 3D. It remains to be
determined if it is time to say ''goodbye to flat HTS''!
DISCLOSURE STATEMENT
No competing financial interests exist.
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Address correspondence to:
Richard M. Eglen, PhD
Corning Life Sciences
836 North Street
Building 300, Suite 3401
Tewksbury, MA 01876
E-mail: eglenrm@corning.com
Abbreviations Used
2D¼two-dimensional
3D¼three-dimensional
ADME¼absorption, distribution, metabolism and excretion
ECM¼extracellular matrix
HCS¼high-content screening
HTS¼high-throughput screening
MAPK¼mitogen-activated protein kinase
PEGs¼polyethylene glycols
PI3K¼phosphoinositide 3-kinase
PSCs¼pluripotent stem cells
30 ASSAY and Drug Development Technologies
ª 2022 MARY ANN LIEBERT, INC.
http://www.corning.com/lifesciences
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