Human Gene Therapy - April 2023 - 249

IN MEMORIAM
249
tory concentrated on the molecular biology of AAV nonstructural
(Rep) proteins and the role that Rep proteins
played in AAV DNA replication and gene expression.
Much of Nick's body of work has become a part of the
AAV canon and is foundational for recombinant AAV
gene therapy.
Although Nick routinely agreed to review articles, his
turnaround time was notoriously long. However, when
asked for input on a project or for laboratory's reagents,
Nick rapidly responded and often the reagents arrived
within a couple of days. Early in my career, I asked Nick if
he would be willing to serve as my reference for job applications.
Nick's response was positive, but with his
characteristic humor: ''I wrote a letter for [this person], so
I guess I can write one for you.'' I got thejob and remained
in contact with Nick through the nearly four decades since.
Rob Kotin
University ofMassachusetts Chan Medical School
Nick, a foundational contributor to AAV gene therapy,
was also a true pioneer in the study of AAV as a virus. He
never stopped working on the critical basic science issues
central to AAV biology, using his insights to guide the
more applied aspects of his work. There were few who
could do both vectorology and virology at his level. He
was a role model as a scientist, and very much appreciated
as a generous caring colleague.
David Pintel
University ofMissouri-Columbia
Nick was such an instrumental component of my scientific
and personal career. I want to share this scientific discussion
from 2021, which was and will always be a rare but
accurate representation of Nick's passion for science and
amazing collaborative nature: https://youtu.be/Usj5mXWisJE
Jude Samulski
University ofNorth Carolina/AskBio
When I was in Nick's laboratory in the mid-late 1980s
for my graduate studies, it was a time of great excitement
and productivity. Nick had attracted an amazing scientific
team to his laboratory who worked on complementary
projects studying transcriptional control, DNA replication,
genetics, and gene transfer; these discoveries and insights
were so interesting and were acquired utilizing the latest
technologies of that time. Over the decades he recruited
strong teams to new enterprises, all while consistently
contributing fundamental understanding and applied aspects
that moved multiple fields forward. He was an excellent
scientific mentor, colleague, and inventor. But above all,
Nick identified interesting and important research areas, and
his science was creative and ofthe highest quality. He leaves
a legacy full of scientific and medical accomplishments that
are in practice now and will perpetuate well into the future.
Richard O. Snyder
Thermo Fisher Scientific
Professor Nicholas Muzyczka will always be remembered
in our hearts as a brilliant, passionate, and dynamic

https://youtu.be/Usj5mXWisJE

Human Gene Therapy - April 2023

Table of Contents for the Digital Edition of Human Gene Therapy - April 2023

Contents
Human Gene Therapy - April 2023 - CT1
Human Gene Therapy - April 2023 - CT2
Human Gene Therapy - April 2023 - Cover1
Human Gene Therapy - April 2023 - Cover2
Human Gene Therapy - April 2023 - 239
Human Gene Therapy - April 2023 - 240
Human Gene Therapy - April 2023 - 241
Human Gene Therapy - April 2023 - 242
Human Gene Therapy - April 2023 - 243
Human Gene Therapy - April 2023 - 244
Human Gene Therapy - April 2023 - Contents
Human Gene Therapy - April 2023 - 246
Human Gene Therapy - April 2023 - 247
Human Gene Therapy - April 2023 - 248
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Human Gene Therapy - April 2023 - Cover3
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