IsoPlexis eBook - 4

I S O P L E X I S ' U N I Q U E , P R E D I C T I V E B I O LO G Y

Introduction
To fully characterize cellular function and

A major challenge in treating many types of cancer is

how it pertains to patient outcomes such as

dealing with the cancer cell's ability to develop drug-

antitumor response or disease progression,

resistance. Genomics has been used to detect

IsoPlexis' single-cell functional cytometry plays a

resistant subpopulations but has not been able to

critical role. IsoPlexis is the only company capable

successfully improve patient outcomes due to cellular

of deep functional multi-omics or complete

functional adaptations. In order to get this valuable

single-cell proteomics: extracellular, intracellular,

information, functional single-cell proteomics must

and metabolomics at single-cell and population

be performed to reveal the adaptive mechanisms of

resolution, using very small sample sizes. And, this is

the path to resistance. IsoPlexis' single-cell intracellular

being done all on one fully automated system, the

proteomics and metabolomics have been used by

IsoLight.

researchers to gain this insight and develop strategies
to overcome drug-induced resistance.

Single-cell proteomics enables accelerated
predictive insights into translational research and

The complete characterization of individual immune

the development of novel immune therapies. CAR-T

and tumor cells is critical in understanding the

therapies have overall demonstrated much success,

functional mechanisms of response to therapy. While

however, treating solid tumors has continued to

the transcriptome is measured using RNA-Seq and

present a challenge. Blood malignancies tend

the cell-surface phenotype bvia flow cytometry,

to be more approachable than the solid tumor

complete cellular definition is incomplete without

microenvironment, both in reaching the target

measuring the true functional phenotype of each cell.

and in understanding how to maintain immune

IsoPlexis' singke-cell proteomic hub has become the

persistence. IsoPlexis' platform provides multi-omic

standard tool to accelerate research and translational

solutions with just one system, automating and

development programs.

simplifying workflows.

4|

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IsoPlexis eBook

Table of Contents for the Digital Edition of IsoPlexis eBook

Contents
IsoPlexis eBook - 1
IsoPlexis eBook - 2
IsoPlexis eBook - Contents
IsoPlexis eBook - 4
IsoPlexis eBook - 5
IsoPlexis eBook - 6
IsoPlexis eBook - 7
IsoPlexis eBook - 8
IsoPlexis eBook - 9
IsoPlexis eBook - 10
IsoPlexis eBook - 11
IsoPlexis eBook - 12
IsoPlexis eBook - 13
IsoPlexis eBook - 14
IsoPlexis eBook - 15
IsoPlexis eBook - 16
IsoPlexis eBook - 17
IsoPlexis eBook - 18
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