IsoPlexis eBook - 6
I S O P L E X I S ' U N I Q U E , P R E D I C T I V E B I O LO G Y
immune persistence remains a challenge. As demon-
acute lymphoblastic leukemia (BL-ALL). An estimated
strated in two recent publications (discussed below),
39% of BL-ALL patients relapse after CD19-directed
IsoPlexis' proteomics platform plays an important
therapies.
role in enabling researchers to predict which T cell
therapies produce persistent results in difficult-totreat situations, such as antigen escape.
Polyfunctional CAR-T cells demonstrate
superior anti-leukemic activity
Fousek and colleagues headed by Hisham AbdelAzim at Children's Hospital Los Angeles and Nabil
IsoPlexis' proteomics platform
plays an important role in enabling
researchers to predict which T cell
therapies produce persistent results
in difficult-to-treat situations,
such as antigen escape.
Ahmed at Baylor College of Medicine recently
published a report on CAR-T cells in Leukemia that
The ubiquitously expressed CD19 is the usual
nicely highlighted IsoPlexis' single-cell functional
target for BL-ALL; however, CD20 is expressed in
phenotyping.1
about 50% of cases and CD22 is expressed in 80-90%.
In pre-clinical settings for both solid and liquid
In addition, CD20 is expressed by almost half of
tumors, combinatorial CAR-T cell therapies have
patients who have mature B-lymphoid neoplasms,
demonstrated a clear advantage. Fousek et al.
which are typically associated with a poor prognosis.
designed a combinatorial CAR-T cell for B-lineage
It is also a predictor of relapse in adult patients when
6|
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IsoPlexis eBook
Table of Contents for the Digital Edition of IsoPlexis eBook
Contents
IsoPlexis eBook - 1
IsoPlexis eBook - 2
IsoPlexis eBook - Contents
IsoPlexis eBook - 4
IsoPlexis eBook - 5
IsoPlexis eBook - 6
IsoPlexis eBook - 7
IsoPlexis eBook - 8
IsoPlexis eBook - 9
IsoPlexis eBook - 10
IsoPlexis eBook - 11
IsoPlexis eBook - 12
IsoPlexis eBook - 13
IsoPlexis eBook - 14
IsoPlexis eBook - 15
IsoPlexis eBook - 16
IsoPlexis eBook - 17
IsoPlexis eBook - 18
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