IsoPlexis eBook - 7

I S O P L E X I S ' U N I Q U E , P R E D I C T I V E B I O LO G Y

present at diagnosis. Antibody therapies targeting

Importantly, IsoPlexis' Single-Cell Adaptive

CD20 are now being used as front-line therapy for

Immune solution demonstrated a marked

adults with BL-ALL.1

upregulation of antigen-specific polyfunctionality

The authors reasoned that broadening the spec-

in CD19/20/22 CAR-T cells compared to CD19 CAR-T

trum of CD19 CAR-T cells to include both CD20 and

cells. Polyfunctional CD19/20/22 CAR-T cells exhibited

CD22 to target multiple antigens could be used as

a greater formation of a functional chimeric antigen

initial, secondary, or salvage therapies. They designed

receptor immune synapse (CARIS) with both CD19-

a CD19/20/22-targeting CAR-T cell by co-expressing

and CD19+ tumor cells, which could enhance their

individual CAR molecules on a single T cell.1 

immunoactivity and prolong tumor-killing ability.

The IsoPlexis platform was used to characterize

When this novel CAR-T product was tested

the novel cell therapy product for effectiveness

in a long-term killing assay, the polyfunctional

and potency. Single-cell functional proteomics

CD19/20/22 CAR-T cells eliminated target cells more

revealed the enhanced polyfunctional profiles of

promptly, sustained over five days of testing.1 This

CD19/20/22 CAR-T cells with robust anti-tumor

combination T cell therapy also effectively

activity in response to CD19+ and CD19- tumor

targeted and demonstrated superior anti-leukemic

cells, supporting a potential advantage of this novel

activity in vivo against CD19-escape BL-ALL and

immunotherapy for patients with recalcitrant disease.

CD19+ BL-ALL.
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IsoPlexis eBook

Table of Contents for the Digital Edition of IsoPlexis eBook

Contents
IsoPlexis eBook - 1
IsoPlexis eBook - 2
IsoPlexis eBook - Contents
IsoPlexis eBook - 4
IsoPlexis eBook - 5
IsoPlexis eBook - 6
IsoPlexis eBook - 7
IsoPlexis eBook - 8
IsoPlexis eBook - 9
IsoPlexis eBook - 10
IsoPlexis eBook - 11
IsoPlexis eBook - 12
IsoPlexis eBook - 13
IsoPlexis eBook - 14
IsoPlexis eBook - 15
IsoPlexis eBook - 16
IsoPlexis eBook - 17
IsoPlexis eBook - 18
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