Vim & Vigor - Summer 2019 - UVA - 31
Help from Growing Therapies
Herbst says he witnessed revolutions since he
started treating lung cancer exclusively about
23 years ago, when the job "really was very grim."
"Treatment was as far from personalized as it
could be," he says.
Now, doctors regularly use immunotherapy
and targeted therapy, which rely on test results
from an individual's cancer to identify and block
cell changes that cause the cancer to grow. Even
with the improvements, lung cancer tumors
often grow back with targeted therapy.
"Cancers are deadly opponents. You have to
treat them with your most modern and innovative things at all times," Herbst says.
And if treatment isn't working, patients with
cancer can try to get accepted to a research trial
for an experimental method.
People who work with cancer hope some treatments become unnecessary as whole-body therapies improve, Schapira says.
"We can imagine a future where surgery
becomes minimal-less disfi guring and less
expansive-and where we also have better ways
of delivering radiation and making it more targeted and less toxic," she says. "And most of
that is going to happen as systemic therapies
get better." ■
CANCER FIGHTERS
Cancer treatment is a combination of three
primary tools-surgery, chemotherapy and
radiation-and other evolving treatments.
Here is what's new in the field.
3 Surgery: Technology advances have
allowed smaller incisions and greater accuracy, decreasing hospital stays.
3 Chemotherapy: A strong partner to
other treatments, this keeps tumors in check
to give the immune system time to attack
or helps when targeted therapy no longer
stops cancer growth. Researchers are seeking new drugs and clarifying the best times
to use chemotherapy.
3 Radiation: With improvement in imaging techniques, radiation can be directed
more exactly.
3 Immunotherapy: Using the body's own
immune system to fight a tumor has become
part of regular care for some cancers.
Researchers are looking for new cell mutations to target.
3 Hormonal therapy: Important for
many years in breast and prostate cancers,
this therapy blocks or lowers the hormones
in the body that some cancers need to grow.
3 Targeted therapy: This is the basis
of precision medicine. Tests of a person's
cancer help identify medicines to interfere
with its growth. Scientists seek new drugs to
interfere in new ways.
3 Bone-marrow transplant: The procedure replenishes stem cells wiped out by
high-dose treatments.
WEBSITE
Top-Ranked
Cancer Care
Cancer services at UVA Health
System rank among the nation's
top 50, according to U.S. News
& World Report. Learn more
about the care we offer at
uvahealth.com/cancer.
S UMME R 2019
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http://www.uvahealth.com/cancer
Vim & Vigor - Summer 2019 - UVA
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Vim & Vigor - Summer 2019 - UVA - Cover2
Vim & Vigor - Summer 2019 - UVA - Contents
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