MD Conference Express - ISTH 2015 - (Page 1)

GLOBAL ADVISORY BOARD Robert P. Guigliano, MD, SM Brigham and Women's Hospital, USA Ashraf Abdelkafy, MD, PhD Suez Canal University, Egypt Kyra Becker, MD Vice Chair, International Stroke Conference 2015, USA Barry P. Boden, MD The Orthopedic Center, USA Christopher M. Bono, MD Brigham and Women's Hospital, USA David Braunreiter, MD Houston Methodist Orthopedics and Sports, USA Brooks Cash, MD University of South Alabama, USA Jean Marie Connors, MD Dana-Farber Cancer Institute, USA W. Hodges Davis, MD OrthoCarolina Foot and Ankle, USA Juliet DeCampos, MD Andrews Institute, USA Patrick Ebeling, MD Twin Cities Orthopedics, USA Tammy Fetterman, RN New York University Medical Center, USA Leena Gandhi, MD, PhD Dana-Farber Cancer Institute, USA C. David Geier, MD Sports Medicine Specialists of Charleston, USA Catherine Geissler, BDS, MS, PhD King's College of London, United Kingdom Shom Goel, MD Dana-Farber Cancer Institute, USA Wolfram Goessling, MD, PhD Dana-Farber Cancer Institute, USA Steven Mark Greenberg, MD, PhD Chair, International Stroke Conference 2015, USA Sarah P. Hammond, MD Brigham and Women's Hospital, USA David M. Jackman, MD Dana-Farber Cancer Institute, USA Douglas B. Johnson, MD, MSCI Vanderbilt University, USA Carroll Jones, MD Carolinas Medical Center-Mercy, USA Nigel Key, MB, ChB, FRCP University of North Carolina, USA Bindee Kuriya, MD, FRCPC, MS University of Toronto, Canada Megan C. Leary, MD Lehigh Valley Hospital and Health Network, USA Nicole R. LeBoeuf, MD Brigham and Women's Hospital, USA Daniel A. Leffler, MD, MS Beth Israel Deaconess Medical Center, USA Philemon A. Lyoka, MD University of Fort Hare, South Africa Elena M. Massarotti, MD Brigham and Women's Hospital, USA Arash Mostaghimi, MD, MPA Brigham and Women's Hospital, USA Kimmie Ng, MD, MPH Dana-Farber Cancer Institute, USA Richard M. Nowak, MD Henry Ford Hospital, USA Caroline Robert, MD, PhD Institut Gustave-Roussy, France Sam Schulman, MD McMaster University, Canada Sara Tolaney, MD, MPH Dana-Farber Cancer Institute, USA Andrew Wagner, MD, PhD Dana-Farber Cancer Institute, USA Jeffrey Weitz, MD McMaster University, Canada Patrick Ying, MD New York University Medical Center, USA Stefano Zaffagnini, MD The Rizzoli Institute, Italy Official Peer-Reviewed Highlights From the International Society on Thrombosis and Haemostasis 2015 Congress FEAtURED ARtIcLES 2 Prevention of Cardiovascular Disease Must Start in Children cLInIcAL tRIAL HIGHLIGHtS 4 RE-VERSE AD: Idarucizumab Safe, Effective for Dabigatran Reversal 6 BRIDGE: Bridging Warfarin With LMWH Increases Bleeding in Patients With AF 6 Recombinant Human Coagulation Factor IX Fc Fusion Protein Effective in Kids B-LONG Study 7 SOME: No Benefit With Extensive Screening for Cancer in Unprovoked VTE 8 Risk Factors for Recurrent Venous Thromboembolism Revealed in PADIS-PE Trial 9 ANNEXA-A: Andexanet alfa Reduces Anti-fXa Activity in Apixaban-Treated Subjects 9 AFFINITY: rVIII-SingleChain Efficacious and Well Tolerated in Pivotal Study 10 PADIS-PE Identifies Risk Factors for Residual Perfusion Defects After Pulmonary Embolism OtHER PEER-REVIEwED ARtIcLES 11 Advances in Understanding and Treatment of Thrombotic Thrombocytopenia Purpura 12 Advances and Potential in Treatment of Hemophilia A 14 Advances in Treatment of Acute Ischemic Stroke 14 Current Treatment of Superficial Vein Thrombosis and Cerebral Venous Thrombosis SELEctED UPDAtES 17 Perioperative Cardiovascular Complications 20 Intrinsic Pathway of Coagulation Offers New Targets to Reduce Thrombosis 22 Management of Posttraumatic Bleeding and Trauma-Induced Coagulopathy 24 A Need for Evidence-Based Answers to Coagulation and Pharmacogenetics 26 Treating Anticoagulant-Associated Bleeding PUBLISHER Society Relationship Manager Elizabeth Donohue Cover Designer Leonardo March Production Editor Stephanie Palermini Tel.: +1-781-897-5249 mdce@sagepub.com mdce.sagepub.com 400 West Cummings Park Suite 4000 Woburn, MA 01801 uSA The Publisher does not assume any legal liability or responsibility for the accuracy, completeness, or usefulness of the information supplied herein, nor for any opinion expressed. The Publisher, its agents, and employees will not be liable for any loss or damage arising directly or indirectly from the possession, publication, use of, or reliance on information obtained from this report. It is provided in good faith without express or implied warranty. reference to any specific commercial product or service does not imply endorsement or recommendation by the Publisher. All articles are peer-reviewed and protected from any commercial influence. © 2015 SAGE Publications. All rights reserved. no portion of the content may be reproduced in any form without the prior written permission of SAGE, which may be reached at permissions@sagepub.com. MD Conference Express is a registered trademark of SAGE Publications. OFFICIAL PEER-REVIEWED HIGHLIGHTS FROM THE HEMATOLOGY Developmental Editors Jennifer Bray Caroline Reich Umair Shafique, MSc Laura Ware PEER-REVIEWED HIGHLIGHTS Executive Director Jennifer Goodwin Schünemann Associate Director, Editorial Development Beth Johnson Senior Manager, Editorial Project Team Claire Stanton Associate Director of Business Operations Mark Danderson Project Managers Irene Berman-Vaporis Audrey Birkett, PhD Cindy Borch IN THIS ISSUE distribution of this independent report is supported by Intrinsic Pathway of Coagulation Offers New Targets to Reduce Thrombosis The intrinsic pathway of coagulation, also called the contact activation pathway (CAP), represents a fertile arena for potential new therapeutic targets to prevent thrombosis yet maintain hemostasis. Unlike treatments that target steps in the extrinsic, or tissue factor, pathway, the risk of bleeding is low or absent when targeting the CAP. The natural triggers of the CAP are less well understood, but work reviewed in this session has increased the understanding of its mechanisms, the role of polyphosphate and immunothrombosis, and the possibility of reducing or eliminating medical device-induced thrombosis. See page 20. ALSO Cover Image: © iStockphoto.com/somersault18:24 ISSN 1559-8977 eISSN 2155-756X 15:21 treating anticoagulantassociated Bleeding clinical trial Highlights Management of Posttraumatic Bleeding and trauma  http://mdce.sagepub.com

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MD Conference Express - ISTH 2015

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