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SOLUBILITY

22. Chan HCS, Kendrick J, Leusen FJJ. Predictability of the polymorphs

38. Sugano K, Kato T, Suzuki K, Keiko K, Sujaku T, Mano T. Highthroughput solubility measurement with automated polarized light

of small organic compounds: crystal structure predictions of

microscopy analysis. J Pharm Sci. 2006;95:2114-2122.

four benchmark blind test molecules. Phys Chem Chem Phys.

39. Diakidou M, Vertzoni M, Goumas K, et al. Characterization of the

2011;13:20361-20370.

contents of ascending colon to which drugs are exposed after oral

23. Sanghvi T, Jain N, Yang G, Yalkowski SH. Estimation of aqueous

administration to healthy adults. Pharm Res. 2009;26:2141-2151.

solubility by the General Solubility Equation (GSE) the easy way. QSAR

40. Kalantzi L, Goumas K, Kalioras V, Abrahamsson B, Dressman JB,

Comb Sci. 2003;22:258-262.

Reppas C. Characterization of the human upper gastrointestinal

24. Hill AP, Young RJ. Getting physical in drug discovery: a contemporary

contents under conditions simulating bioavailability/bioequivalence

perspective on solubility and hydrophobicity. Drug Discov Today.
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studies. Pharm Res. 2006;23:165-176.
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examining carbo- and hetero-aromatic and -aliphatic ring types. Drug

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David Elder, PhD, studied chemistry at Newcastle upon Tyne (BSc, MSc)

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before moving to Edinburgh to study for a PhD in Crystallography. Dr.

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discovery. J Pharm Sci. 2001;90:1838-1858.

Elder has 37 years of experience at a variety of different pharmaceutical
companies (Sterling, Syntex, and GSK). He is currently the principal consultant at David P. Elder Consultancy. He has seven patents to his name.
Christoph Saal, PhD, studied chemistry at the Technical University of
Darmstadt and graduated in Physical Chemistry. In 1999, he joined
Merck KGaA, where he held several positions within Analytical and

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Medicinal Chemistry. Currently, Christoph Saal is heading a group

thermodynamic solubility-temptations and risks. Eur J Pharm Sci.

focused on analytical and physicochemical characterization of New

2012;47,589-595.

Chemical Entities.
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Seqens eBook

Table of Contents for the Digital Edition of Seqens eBook

Contents
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Seqens eBook - Contents
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