Anacetrapib Effects on LDL-C and HDL-C 100 LDL-C 120 100 HDL-C 80 LDL-C (mg/dL) (SE) 60 -39.8% (P<0.001) HDL-C (mg/dL) (SE) 80 60 40 20 0 +138.1% (P<0.001) 40 Anacetrapib Placebo Baseline 20 Anacetrapib Placebo Baseline 0 6 12 18 24 30 46 62 76 6 12 18 24 30 46 62 76 Study Week Anacetrapib n = 804 771 716 687 646 Placebo n = 803 759 741 743 735 604 711 568 691 540 666 Study Week Anacetrapib n = 776 757 718 687 647 Placebo n = 766 761 741 744 736 607 711 572 691 543 666 Cannon CP et al. N Engl J Med. 2010;363:2406-2415.