Hospital Pharmacy - June 2019 - 178

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Hospital Pharmacy 54(3)

Figure 1. Factors influencing and deterring carbapenem use among providers.

Note. Figure 1a represents factors influencing carbapenem prescription in order of most important to least important. Figure 1b represents factors
deterring carbapenem use in order of most likely to least likely. MDR = multidrug resistant; rec. = recommendation; ID = infectious disease service.

Table 2. Multiple-Choice Survey Questions and Answers.
Answer choice

PGY-1

PGY-2

PGY-3

PGY-4, 5,
or fellow

Attending
physician

Overall

Question 1. Which of the following statements is correct regarding penicillin drug allergy and beta-lactam cross reactivity?
All carbapenems and cephalosporins have similar rates of
17.0%
11.5%
5.4%
35.7%
15.8%
17.0%
cross reactivity
Carbapenems and advanced-generation cephalosporins have low
51.1%
53.9%
66.7%
35.7%
52.6%
51.1%
(i.e. ≤1%) rates of cross reactivity
Carbapenems do not pose a risk for cross reactivity
9.6%
7.7%
5.6%
7.2%
10.5%
9.6%
Carbapenems have a lower likelihood of cross reactivity
22.3%
26.9%
22.3%
21.4%
21.1%
22.3%
than cefepime
Question 2. Based on the institutional antibiogram, which of the following antibiotics is P aeruginosa most likely to be susceptible to?
Piperacillin-tazobactam
47.4%
42.3%
47.4%
50.0%
42.1%
47.4%
Cefepime
29.5%
23.1%
36.8%
42.9%
36.8%
29.5%
Aztreonam
4.2%
3.9%
5.3%
0.0%
5.3%
4.2%
Meropenem
18.9%
30.7%
10.5%
7.1%
15.8%
18.9%
Question 3. True or false. Beta-lactam/beta-lactamase inhibitors (i.e. piperacillin-tazobactam) are inferior to carbapenems to treat
bloodstream infections caused by ESBL-producing Enterobacteriaceae from low inoculum sources of infection (i.e. urinary, biliary).
True
52.6%
57.7%
52.6%
64.3%
36.8%
52.6%
False
47.4%
42.3%
47.4%
35.7%
63.2%
47.4%
Note. Correct responses for each question denoted by italicized font. PGY = postgraduate year; ESBL = extended-spectrum beta-lactamase.

evidence supporting the use of BLBLIs in the treatment of
infections caused by ESBL-producing Enterobacteriaceae,
despite evidence showing BLBLIs to be an equally efficacious, carbapenem-sparing option for the treatment of
these infections in certain scenarios.7 Based on these
results, providers may have an underappreciation of the
value of local susceptibility rates when choosing to use a
carbapenem, and misconceptions in both of these areas
may contribute to carbapenem overutilization.

Another finding of this survey is that despite the presence
of drug allergies being identified as one of the most important factors considered when prescribing a carbapenem, only
about half of respondents selected that there is an equal
(albeit low) likelihood for patients with a history of an immediate hypersensitivity reaction to penicillin to also have an
allergic reaction to a carbapenem or advanced-generation
cephalosporin. Nearly one-quarter of respondents suggested
that carbapenems pose a lower risk of cross reactivity than



Hospital Pharmacy - June 2019

Table of Contents for the Digital Edition of Hospital Pharmacy - June 2019

TOC/Verso
The Future CPOE Workflow: Augmenting Clinical Decision Support With Pharmacist Expertise
Contributing Factors to Perceptions of Residents’ Statistical Abilities
Mix-Ups Between Epidural Analgesia and IV Antibiotics in Labor and Delivery Units Continue to Cause Harm
Acute Hepatotoxicity After High-Dose Cytarabine for the Treatment of Relapsed Acute Myeloid Leukemia: A Case Report
Baloxavir Marboxil
Integration of an Academic Medical Center and a Large Health System: Implications for Pharmacy
The Culture of Carbapenem Overconsumption. : Where Does It Begin? Results of a Single-Center Survey
Clinical Pharmacist Impact on Intensive Care Unit Delirium: Intervention and Monitoring
A Case Report of Hypertensive Emergency and Intracranial Hemorrhage Due to Intracavernosal Phenylephrine
Stability of Meropenem After Reconstitution for Administration by Prolonged Infusion
Hypoglycemia Associated With Insulin Use During Treatment of Hyperkalemia Among Emergency Department Patients
Impact of Implementing Smart Infusion Pumps in an Intensive Care Unit in Mexico: A Pre-Post Cost Analysis Based on Intravenous Solutions Consumption
Hospital Pharmacy - June 2019 - Cover1
Hospital Pharmacy - June 2019 - Cover2
Hospital Pharmacy - June 2019 - 137
Hospital Pharmacy - June 2019 - 138
Hospital Pharmacy - June 2019 - 139
Hospital Pharmacy - June 2019 - 140
Hospital Pharmacy - June 2019 - 141
Hospital Pharmacy - June 2019 - 142
Hospital Pharmacy - June 2019 - 143
Hospital Pharmacy - June 2019 - 144
Hospital Pharmacy - June 2019 - 145
Hospital Pharmacy - June 2019 - 146
Hospital Pharmacy - June 2019 - TOC/Verso
Hospital Pharmacy - June 2019 - 148
Hospital Pharmacy - June 2019 - The Future CPOE Workflow: Augmenting Clinical Decision Support With Pharmacist Expertise
Hospital Pharmacy - June 2019 - 150
Hospital Pharmacy - June 2019 - 151
Hospital Pharmacy - June 2019 - 152
Hospital Pharmacy - June 2019 - Contributing Factors to Perceptions of Residents’ Statistical Abilities
Hospital Pharmacy - June 2019 - 154
Hospital Pharmacy - June 2019 - Mix-Ups Between Epidural Analgesia and IV Antibiotics in Labor and Delivery Units Continue to Cause Harm
Hospital Pharmacy - June 2019 - 156
Hospital Pharmacy - June 2019 - 157
Hospital Pharmacy - June 2019 - 158
Hospital Pharmacy - June 2019 - 159
Hospital Pharmacy - June 2019 - Acute Hepatotoxicity After High-Dose Cytarabine for the Treatment of Relapsed Acute Myeloid Leukemia: A Case Report
Hospital Pharmacy - June 2019 - 161
Hospital Pharmacy - June 2019 - 162
Hospital Pharmacy - June 2019 - 163
Hospital Pharmacy - June 2019 - 164
Hospital Pharmacy - June 2019 - Baloxavir Marboxil
Hospital Pharmacy - June 2019 - 166
Hospital Pharmacy - June 2019 - 167
Hospital Pharmacy - June 2019 - 168
Hospital Pharmacy - June 2019 - 169
Hospital Pharmacy - June 2019 - Integration of an Academic Medical Center and a Large Health System: Implications for Pharmacy
Hospital Pharmacy - June 2019 - 171
Hospital Pharmacy - June 2019 - 172
Hospital Pharmacy - June 2019 - 173
Hospital Pharmacy - June 2019 - 174
Hospital Pharmacy - June 2019 - The Culture of Carbapenem Overconsumption. : Where Does It Begin? Results of a Single-Center Survey
Hospital Pharmacy - June 2019 - 176
Hospital Pharmacy - June 2019 - 177
Hospital Pharmacy - June 2019 - 178
Hospital Pharmacy - June 2019 - 179
Hospital Pharmacy - June 2019 - Clinical Pharmacist Impact on Intensive Care Unit Delirium: Intervention and Monitoring
Hospital Pharmacy - June 2019 - 181
Hospital Pharmacy - June 2019 - 182
Hospital Pharmacy - June 2019 - 183
Hospital Pharmacy - June 2019 - 184
Hospital Pharmacy - June 2019 - 185
Hospital Pharmacy - June 2019 - A Case Report of Hypertensive Emergency and Intracranial Hemorrhage Due to Intracavernosal Phenylephrine
Hospital Pharmacy - June 2019 - 187
Hospital Pharmacy - June 2019 - 188
Hospital Pharmacy - June 2019 - 189
Hospital Pharmacy - June 2019 - Stability of Meropenem After Reconstitution for Administration by Prolonged Infusion
Hospital Pharmacy - June 2019 - 191
Hospital Pharmacy - June 2019 - 192
Hospital Pharmacy - June 2019 - 193
Hospital Pharmacy - June 2019 - 194
Hospital Pharmacy - June 2019 - 195
Hospital Pharmacy - June 2019 - 196
Hospital Pharmacy - June 2019 - Hypoglycemia Associated With Insulin Use During Treatment of Hyperkalemia Among Emergency Department Patients
Hospital Pharmacy - June 2019 - 198
Hospital Pharmacy - June 2019 - 199
Hospital Pharmacy - June 2019 - 200
Hospital Pharmacy - June 2019 - 201
Hospital Pharmacy - June 2019 - 202
Hospital Pharmacy - June 2019 - Impact of Implementing Smart Infusion Pumps in an Intensive Care Unit in Mexico: A Pre-Post Cost Analysis Based on Intravenous Solutions Consumption
Hospital Pharmacy - June 2019 - 204
Hospital Pharmacy - June 2019 - 205
Hospital Pharmacy - June 2019 - 206
Hospital Pharmacy - June 2019 - 207
Hospital Pharmacy - June 2019 - 208
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