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Al-Quteimat and Laila
in some patients. Other antimicrobial agents should be considered as alternatives to carbapenem antibiotics. Replacing
VPA with another non-interacting antiepileptic agent or prescribing additional antiepileptic medication can be an option.
Therapeutic drug monitoring of valproate concentration is
warranted when a carbapenem-VPA combination therapy is
necessary, especially on initiating or stopping the carbapenem antibiotic.
Acknowledgments
The authors of this review would like to thank Mr. Hassan Al Tomy,
BS Pharm, MS, BCPS, for his continuous support and help in
obtaining the full text of many related publications.

Declaration of Conflicting Interests
The author(s) declared no potential conflicts of interest with respect
to the research, authorship, and/or publication of this article.

Funding
The author(s) received no financial support for the research, authorship, and/or publication of this article.

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Hospital Pharmacy - June 2020

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