Hospital Pharmacy - October 2019 - 296
296
Hospital Pharmacy 54(5)
Table 1. Baseline Demographic and Clinical Parameters.
Age, median (IQR)
Female, n (%)
Ethnicity, n (%)
African American
Caucasian
Hispanic
Other/nonspecified
Length of stay prior to diagnosis, days, median (IQR)
Location at diagnosis, n (%)
ED
General medicine floor
ICU
Intermediate Care
Patients with previous CDI episodes treated with metronidazole, n (%)
Tmax at Diagnosis, F, median (IQR)
Fever/hypothermia at diagnosis, n (%)
WBC count at diagnosis, median (IQR)
SCr Dx/SCr Premorbid ratio ⩾ 1.5 (n = 109), n (%)
Albumin (n = 95), median (IQR)
Fulminant CDI, n (%)
iVAN
(n = 101)
dVAN
(n = 20)
67 (52.0-79.0)
46 (45.54%)
72.5 (51.5-80.0)
13 (65.00%)
23 (22.77%)
67 (66.34%)
10 (9.90%)
1 (0.99%)
1.0 (0.0-6.0)
37 (36.63%)
42 (41.58%)
19 (18.81%)
3 (2.97%)
17 (16.83)
99.4 (98.7-100.6)
26 (25.74%)
21.4 (18.1-27.9)
44 (47.83%)
2.6 (2.2-3.0)
20 (19.80%)
4 (20.00%)
13 (65.00%)
2 (10.00%)
1 (5.00%)
2.5 (1.0-9.5)
5 (25.00%)
10 (50.00%)
4 (20.00%)
1 (5.00%)
1 (5.00%)
99.8 (98.8-100.4)
4 (20.00%)
19.3 (16.9-25.8)
7 (41.18%)
2.7 (2.2-2.3)
5 (25.00%)
P value
.52
.11
.60
.09
.64
.30
.73
.78
.19
.61
.96
.56
Note. iVAN = initial oral vancomycin; dVAN = delayed oral vancomycin; IQR = interquartile range; ED = emergency department; ICU = intensive care
unit; CDI = Clostridium difficile infection; Tmax = temperature maximum; WBC = white blood cell; SCr Dx = Serum creatinine at diagnosis of Clostridium
difficile infection.
Table 2. Treatment Information.
Time to oral VAN, days, median (IQR)
Initial oral VAN dose, n (%)
125 mg
250 mg
500 mg
Combination therapy any time, n (%)
Combination therapy within 24 hours of diagnosis, n (%)
Concurrent treatment, n (%)
MDZ IV 500mg
MDZ PO 500mg
VAN enema
Days of hospital treatment, median (IQR)
Total days of treatment, median (IQR)
Discharged before finishing treatment, n (%)
Any concurrent antibiotic, n (%)
Number of concurrent antibiotics, median (IQR)
Antibiotics within 90 days, n (%)
Number antibiotics within 90 days, median (IQR)
Prior antibiotic within 90 days, n (%)
Penicillins
ß-lactam/ß-lactamase
1st or 2nd generation cephalosporin
3rd generation or greater cephalosporin
iVAN
(n = 101)
dVAN
(n = 20)
P value
0.33 (0.0-0.82)
3.2 (2.7-5.4)
<.001
79 (78.22%)
14 (13.86%)
8 (7.92%)
84 (83.17%)
66 (65.35%)
12 (60.00%)
5 (25.00%)
3 (15.00%)
18 (90.00%)
0 (0.00%)
.17
.74
<.001
74 (73.27%)
39 (38.61%)
3 (2.97%)
7.0 (4.0-11.3)
14.0 (13.8-15.0)
73 (72.28%)
54 (53.47%)
1.0 (0.0-2.0)
75 (74.26%)
2.0 (0.0-3.0)
17 (85.00%)
14 (70.00%)
0 (0.00%)
13.2 (8.4-16.7)
16.5 (13.8-22.2)
10 (50.00%)
14 (70.00%)
1.0 (0.0-2.0)
16 (80.00%)
2.0 (1.0-3.0)
.40
.01
1.00
<.001
.06
.05
.17
.16
.78
.56
9 (8.91%)
15 (14.85%)
18 (17.82%)
40 (39.60%)
0 (0.00%)
5 (25.00%)
5 (25.00%)
8 (40.00%)
.35
.32
.53
.97
(continued)
Hospital Pharmacy - October 2019
Table of Contents for the Digital Edition of Hospital Pharmacy - October 2019
TOC/Verso
Disrespectful Behavior in Health System Pharmacy Practice: Consequences and Next Steps
The Orphan Drug Act: An Appropriate Approval Pathway for Treatments of Rare Diseases?
Significant Published Articles for Pharmacy Nutrition Support Practice in 2018
Impact of Delayed Oral Vancomycin for Severe Clostridium difficile Infection
Evaluation of a Hospital Pharmacist Annual Competency Program
A Retrospective Analysis of Adherence to Risk Evaluation and Mitigation Strategies Requirements for Pulmonary Arterial Hypertension Drugs
Impact of an Advanced Pharmacy Practice Experience Student-Run “Meds 2 Beds” and Discharge Counseling Program on Quality of Care
A Retrospective Surveillance of the Antibiotics Prophylactic Use of Surgical Procedures in Private Hospitals in Indonesia
Stability and Compatibility of Diphenhydramine Hydrochloride in Intravenous Admixtures: A New Look at an Old Drug
The Impact of an Automated Dispensing System for Supplying Narcotics in a Surgical Unit: The Experience of the National Cancer Institute Foundation of Milan
Hospital Pharmacy - October 2019 - Cover1
Hospital Pharmacy - October 2019 - Cover2
Hospital Pharmacy - October 2019 - 277
Hospital Pharmacy - October 2019 - TOC/Verso
Hospital Pharmacy - October 2019 - 279
Hospital Pharmacy - October 2019 - Disrespectful Behavior in Health System Pharmacy Practice: Consequences and Next Steps
Hospital Pharmacy - October 2019 - 281
Hospital Pharmacy - October 2019 - 282
Hospital Pharmacy - October 2019 - The Orphan Drug Act: An Appropriate Approval Pathway for Treatments of Rare Diseases?
Hospital Pharmacy - October 2019 - 284
Hospital Pharmacy - October 2019 - Significant Published Articles for Pharmacy Nutrition Support Practice in 2018
Hospital Pharmacy - October 2019 - 286
Hospital Pharmacy - October 2019 - 287
Hospital Pharmacy - October 2019 - 288
Hospital Pharmacy - October 2019 - 289
Hospital Pharmacy - October 2019 - 290
Hospital Pharmacy - October 2019 - 291
Hospital Pharmacy - October 2019 - 292
Hospital Pharmacy - October 2019 - 293
Hospital Pharmacy - October 2019 - Impact of Delayed Oral Vancomycin for Severe Clostridium difficile Infection
Hospital Pharmacy - October 2019 - 295
Hospital Pharmacy - October 2019 - 296
Hospital Pharmacy - October 2019 - 297
Hospital Pharmacy - October 2019 - 298
Hospital Pharmacy - October 2019 - 299
Hospital Pharmacy - October 2019 - Evaluation of a Hospital Pharmacist Annual Competency Program
Hospital Pharmacy - October 2019 - 301
Hospital Pharmacy - October 2019 - 302
Hospital Pharmacy - October 2019 - 303
Hospital Pharmacy - October 2019 - 304
Hospital Pharmacy - October 2019 - 305
Hospital Pharmacy - October 2019 - 306
Hospital Pharmacy - October 2019 - 307
Hospital Pharmacy - October 2019 - 308
Hospital Pharmacy - October 2019 - A Retrospective Analysis of Adherence to Risk Evaluation and Mitigation Strategies Requirements for Pulmonary Arterial Hypertension Drugs
Hospital Pharmacy - October 2019 - 310
Hospital Pharmacy - October 2019 - 311
Hospital Pharmacy - October 2019 - 312
Hospital Pharmacy - October 2019 - 313
Hospital Pharmacy - October 2019 - Impact of an Advanced Pharmacy Practice Experience Student-Run “Meds 2 Beds” and Discharge Counseling Program on Quality of Care
Hospital Pharmacy - October 2019 - 315
Hospital Pharmacy - October 2019 - 316
Hospital Pharmacy - October 2019 - 317
Hospital Pharmacy - October 2019 - 318
Hospital Pharmacy - October 2019 - 319
Hospital Pharmacy - October 2019 - 320
Hospital Pharmacy - October 2019 - 321
Hospital Pharmacy - October 2019 - 322
Hospital Pharmacy - October 2019 - A Retrospective Surveillance of the Antibiotics Prophylactic Use of Surgical Procedures in Private Hospitals in Indonesia
Hospital Pharmacy - October 2019 - 324
Hospital Pharmacy - October 2019 - 325
Hospital Pharmacy - October 2019 - 326
Hospital Pharmacy - October 2019 - 327
Hospital Pharmacy - October 2019 - 328
Hospital Pharmacy - October 2019 - 329
Hospital Pharmacy - October 2019 - Stability and Compatibility of Diphenhydramine Hydrochloride in Intravenous Admixtures: A New Look at an Old Drug
Hospital Pharmacy - October 2019 - 331
Hospital Pharmacy - October 2019 - 332
Hospital Pharmacy - October 2019 - 333
Hospital Pharmacy - October 2019 - 334
Hospital Pharmacy - October 2019 - The Impact of an Automated Dispensing System for Supplying Narcotics in a Surgical Unit: The Experience of the National Cancer Institute Foundation of Milan
Hospital Pharmacy - October 2019 - 336
Hospital Pharmacy - October 2019 - 337
Hospital Pharmacy - October 2019 - 338
Hospital Pharmacy - October 2019 - 339
Hospital Pharmacy - October 2019 - 340
Hospital Pharmacy - October 2019 - 341
Hospital Pharmacy - October 2019 - 342
Hospital Pharmacy - October 2019 - 343
Hospital Pharmacy - October 2019 - 344
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