Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts - P110

Otology/Neurotology

P110
Otolaryngology-Head and Neck Surgery 163(1S)
Presentation schedule is subject to change. The Official Program Abstracts supplement does not reflect changes made after August 10, 2020.
in the Dix-Hallpike maneuver (DHM). The objective was to
delayed onset facial palsy to ataxia and increased intracranial
estimate the short-term efficacy of the Epley maneuver as a
pressure. Three patients (15%) were formerly anticoagulated
treatment for S-BPPV.
over a 3- to 6-month period, without any complications.
Methods: Prospective study of patients with S-BPPV who
Conclusions: SST affects a significant proportion of patients
attended the Department of Otorhinolaryngology and Head and
undergoing lateral skull base procedures. We were able to
Neck Surgery in a secondary care center from October 2018 to
identify factors that may help establish which patients are at
October 2019. Inclusion criteria included unilateral S-BPPV
higher risk of developing SST. The decision to initiate sysdemonstrated by negative DHM to nystagmus but positive unilattemic anticoagulation must be made on a case-by-case basis.
eral symptoms (dizziness or vertigo). Intervention: Epley maneuver to the involved side and Dizziness Handicap Inventory
Sodium Fluorescein Uptake via OATP1 in
(DHI) was performed in all patients; at 1-week f- ollow-up, DHI
Vestibular Schwannomas
and DHM were repeated. The outcome measurements were
Stefanie Peña (Presenter); Cristina Fernandez-Valle, PhD;
resolution of symptoms during DHM and improvement of DHI
Xue-Zhong Liu, MD, PhD; Fred F. Telischi, MEE, MD;
scores. Patients were divided into resolved and unresolved
Michael Ivan; Christine Thuyvan Dinh, MD
groups according to the 1-week DHM. Student t test and quanObjectives: Vestibular schwannomas (VS) are tumors of the
titative values were reported as mean and standard deviation.
cochleovestibular nerve that develop from neurofibromatosis
Results: Thirteen participants, 12 women and 1 man, mean
type 2 mutations that cause merlin dysfunction and/or loss.
age 53.31 years (SD +15.71). The right ear was involved in
Sodium fluorescein (SF) is a fluorescent compound, and its
46.15% and left in 53.8%. Six of 13 patients (46.15%) had
use may be advantageous in VS surgery by helping surgeons
resolution of symptoms. DHI initial score for the resolved
distinguish the tumor-nerve interface. Organic anion transgroup was 36.22 + 22 and for the unresolved group was 39.71
porting polypeptides (OATPs) have been demonstrated to play
+ 19.61 (P = .524). At 1 week, evaluation scores were 19.66 +
a role in the transport of SF. We hypothesize that VS has pref25.05 for the resolved group and 30.28 + 21.42 for the unreerential uptake of SF by expressing more OATP1 transmemsolved group (P = .707). DHI improvement was 15.00 + 23.21
brane proteins.
and 9.42 + 10.17 for each group, respectively (P = .020).
Methods: Western blot (WB) was performed to determine the
Conclusions: The Epley maneuver is an effective short-term
levels of OATP1 expression in normal human Schwann cells,
treatment for S-BPPV. Half of the patients would need further
human merlin-deficient Schwann cells (MD-SC), and cultured
diagnostic tests.
primary VS (n = 6). Immunofluorescence was performed with
Sigmoid Sinus Thrombosis Following
confocal microscopy to confirm the location of OATP1 on the
CPA Tumor Resection: Incidence, Clinical
plasma membrane. Subsequently, we cultured cells on 96-well
Manifestations, and Therapeutic Dilemma
plates for 3 hours with various concentrations of SF and OATP1
inhibitors (lapatinib, trametinib). To determine the degree of
Mathieu Trudel, MD (Presenter); Scott A. Rutherford, FRCSEd;
SF uptake, the fluorescence intensities were measured using a
Luc Djoumessi, MD; Simon R. M. Freeman, FRCS;
fluorometer (excitation ~475 nm; emission ~500-550 nm).
Emma Stapleton; Simon K. W. Lloyd, FRCS
Statistical analysis will be performed with parametric and nonObjectives: Sigmoid sinus thrombosis (SST) is a rare but
parametric analysis of variance with significance set at P < .05.
potentially life-threatening surgical complication associated
Results: On WB, we found that MD-SCs and primary VS
with posterior fossa approaches. The aims of this study are to
have higher expression levels of OATP1 than normal human
establish the clinical prevalence of SST in adult patients
Schwann cells. On immunofluorescence, OATP1 is localized
undergoing lateral skull base surgeries; to identify the patient,
primarily on the plasma membrane of MD-SCs and primary
surgical, and tumoral factors affecting its development; and to
VS. In addition, we demonstrated that inhibition of OATP1 in
assess the therapeutic efficacy and determine the complication
MD-SCs and primary VS cells resulted in less SF uptake, as
rate of systemic anticoagulation.
reflected by reductions in fluorescence intensities.
Methods: We performed a retrospective review of all adult
Conclusions: These findings support further investigations
patients who had a cerebellopontine angle (CPA) lesion
into the clinical utility of SF for improving tumor resection
resected through a translabyrinthine or a retrosigmoid approach
and surgical outcomes during VS surgery.
between January 2016 and December 2019 at a single tertiary
care referral center.
Sustained Long-term Hearing
Results: A total of 212 patients were included in the study.
Improvements After a Single Intratympanic
Following surgery, 20 patients (9.4%) had a radiologically
Dose of FX-322, a Cochlear Progenitor Cell
confirmed SST. Most patients who suffered from this compliActivator
cation were operated through a translabyrinthine approach
Susan M. King, MD (Presenter); Robyn Shanley, PhD, AuD;
(18/20) and had histologically confirmed vestibular schwanJenna Herby; Grace Fitzgerald; Sam Wilson, PhD; Carl P.
nomas (19/20). Although 6 patients (30%) were completely
LeBel, PhD
asymptomatic, clinical manifestations developed between
1 day and 2 months postoperatively (median: 5 days). Patients
Objectives: Previous work showed that two small molecules
experienced various symptoms ranging from headache and
comprising FX-322 restore sensory hair cells and hearing

Otolaryngology - Head & Neck Surgery Supplement - 2020 Official Program Abstracts

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