Pulse - August 2022 - 13

PRACTICAL PATHOLOGY
Canine Herpesvirus in Puppies
Farshid Shahriar, DVM, PhD, Dipl ACVP - Lab For Pets, Tustin, CA
Medical history and clinical findings:
Two puppies from a litter of 5 were submitted for necropsy. All
puppies in the litter had the same disease crying and dying a few
days after showing clinical sing of not eating and lethargy.
Gross exam and histopathologic findings:
Carcasses were in good postmortem preservation. Oral and conjunctival
mucous membranes were congested. Lungs were edematous,
voluminous, congested and slightly firm on palpation (Fig.
1). Liver was congressed. Both kidneys have multifocal petechial
hemorrhage on the surface and hemorrhage within the parenchyma.
(Fig. 2). Histologically, lungs had acute pulmonary necrosis
with multifocal areas of suppurative pneumonia. (Fi.3). Liver
tissue showed multifocal hepatic necrosis with rare intra-nuclear
inclusion bodies. (Fig. 4). There was multifocal to coalescing renal
necrosis with parenchymal and subcapsular hemorrhage. Intestinal,
splenic necrosis and meningitis with pleomorphic inflammation
were also detected.
Diagnosis:
Diagnosis of a Herpesvirus infection with multi-organ involvement
was made.
Discussion:
Canine herpesvirus type 1 also known as Fading puppy syndrome
is a well-known disease in death of neonates and newborns. Dogs
less than 3 weeks old generally have fatal systemic disease due to
acute neonatal infection. Dogs older than 3 weeks can have lesion
in eye and respiratory infection. Non-exposed pregnant bitches are
susceptible to systemic infection that can cause abortions or acute
neonatal viremia. Puppies acquire the disease through in utero,
passage through the birth canal, direct contact with oronasal secretions
of the bitch, direct contact with other dogs that are shedding,
and humans acting as fomites. The time from when the puppy is
initially infected until it shows symptoms is four to six days, and
the onset is sudden. After clinical signs appear, death usually occurs
in 24 to 36 hours. Some puppies with mild signs may survive but
can later develop serious neurological issues, such as trouble walking
and blindness. There is almost a 100% mortality rate. Common
clinical signs include vocalization, anorexia, hypothermia, abdominal
pain, and/or incoordination.
Prevention is the best way for management and treatment of
this disease. Since the virus is spread primarily by air and direct
contact with nasal secretions, sanitation is an important part of
prevention. Crowded conditions should be avoided. Mother and
puppies also should be kept separate for the first three weeks after
birth. Puppies nursing from bitches that have previously been
exposed to the virus are resistant to infection as they receive antibodies
from colostrum. P
PULSE
AUGUST 2022
Figure 1
Figure 2
Figure 3
Figure 4
13

Pulse - August 2022

Table of Contents for the Digital Edition of Pulse - August 2022

Pulse - August 2022
Chapter Meetings & Calendar
President’s Perspective
Pulsepoints
SCVMA Profile
COVER FEATURE STORY
Practical Pathology
UC Davis Update
Tools for Success
Angel Fund
The RVT
Industry Insights
Digital Photography for Veterinarians
AVMA Diplomates
Resources
Disease Table
From the SCVMA Office
Pulse - August 2022 - Pulse - August 2022
Pulse - August 2022 - Cover2
Pulse - August 2022 - 1
Pulse - August 2022 - 2
Pulse - August 2022 - Chapter Meetings & Calendar
Pulse - August 2022 - President’s Perspective
Pulse - August 2022 - Pulsepoints
Pulse - August 2022 - 6
Pulse - August 2022 - 7
Pulse - August 2022 - 8
Pulse - August 2022 - SCVMA Profile
Pulse - August 2022 - COVER FEATURE STORY
Pulse - August 2022 - 11
Pulse - August 2022 - 12
Pulse - August 2022 - Practical Pathology
Pulse - August 2022 - UC Davis Update
Pulse - August 2022 - Tools for Success
Pulse - August 2022 - Angel Fund
Pulse - August 2022 - The RVT
Pulse - August 2022 - Digital Photography for Veterinarians
Pulse - August 2022 - 19
Pulse - August 2022 - 20
Pulse - August 2022 - 21
Pulse - August 2022 - 22
Pulse - August 2022 - AVMA Diplomates
Pulse - August 2022 - Resources
Pulse - August 2022 - Disease Table
Pulse - August 2022 - 26
Pulse - August 2022 - 27
Pulse - August 2022 - 28
Pulse - August 2022 - 29
Pulse - August 2022 - 30
Pulse - August 2022 - 31
Pulse - August 2022 - 32
Pulse - August 2022 - 33
Pulse - August 2022 - 34
Pulse - August 2022 - 35
Pulse - August 2022 - 36
Pulse - August 2022 - 37
Pulse - August 2022 - 38
Pulse - August 2022 - 39
Pulse - August 2022 - 40
Pulse - August 2022 - 41
Pulse - August 2022 - 42
Pulse - August 2022 - 43
Pulse - August 2022 - From the SCVMA Office
Pulse - August 2022 - Cover3
Pulse - August 2022 - Cover4
https://www.nxtbook.com/nxtbooks/scvma/pulse_202501
https://www.nxtbook.com/nxtbooks/scvma/pulse_202412
https://www.nxtbook.com/nxtbooks/scvma/pulse_202411
https://www.nxtbook.com/nxtbooks/scvma/pulse_202410
https://www.nxtbook.com/nxtbooks/scvma/pulse_202409
https://www.nxtbook.com/nxtbooks/scvma/pulse_202408
https://www.nxtbook.com/nxtbooks/scvma/pulse_202407
https://www.nxtbook.com/nxtbooks/scvma/pulse_202406
https://www.nxtbook.com/nxtbooks/scvma/pulse_202405
https://www.nxtbook.com/nxtbooks/scvma/pulse_202404
https://www.nxtbook.com/nxtbooks/scvma/pulse_202403
https://www.nxtbook.com/nxtbooks/scvma/pulse_202402
https://www.nxtbook.com/nxtbooks/scvma/pulse_202401
https://www.nxtbook.com/nxtbooks/scvma/pulse_202312
https://www.nxtbook.com/nxtbooks/scvma/pulse_202311
https://www.nxtbook.com/nxtbooks/scvma/pulse_202310
https://www.nxtbook.com/nxtbooks/scvma/pulse_202309
https://www.nxtbook.com/nxtbooks/scvma/pulse_202308
https://www.nxtbook.com/nxtbooks/scvma/pulse_202307
https://www.nxtbook.com/nxtbooks/scvma/pulse_202306
https://www.nxtbook.com/nxtbooks/scvma/pulse_202305
https://www.nxtbook.com/nxtbooks/scvma/pulse_202304
https://www.nxtbook.com/nxtbooks/scvma/pulse_202303
https://www.nxtbook.com/nxtbooks/scvma/pulse_202302
https://www.nxtbook.com/nxtbooks/scvma/pulse_202301
https://www.nxtbook.com/nxtbooks/scvma/pulse_202212
https://www.nxtbook.com/nxtbooks/scvma/pulse_202211
https://www.nxtbook.com/nxtbooks/scvma/pulse_202210
https://www.nxtbook.com/nxtbooks/scvma/pulse_202209
https://www.nxtbook.com/nxtbooks/scvma/pulse_202208
https://www.nxtbook.com/nxtbooks/scvma/pulse_202207
https://www.nxtbook.com/nxtbooks/scvma/pulse_202206
https://www.nxtbook.com/nxtbooks/scvma/pulse_202205
https://www.nxtbook.com/nxtbooks/scvma/pulse_202204
https://www.nxtbook.com/nxtbooks/scvma/pulse_202203
https://www.nxtbook.com/nxtbooks/scvma/pulse_202202
https://www.nxtbook.com/nxtbooks/scvma/pulse_202201
https://www.nxtbook.com/nxtbooks/scvma/pulse_202112
https://www.nxtbook.com/nxtbooks/scvma/pulse_202111
https://www.nxtbook.com/nxtbooks/scvma/pulse_202110
https://www.nxtbook.com/nxtbooks/scvma/pulse_202109
https://www.nxtbook.com/nxtbooks/scvma/pulse_202108
https://www.nxtbook.com/nxtbooks/scvma/pulse_202107
https://www.nxtbook.com/nxtbooks/scvma/pulse_202106
https://www.nxtbook.com/nxtbooks/scvma/scvma/pulse_202105
https://www.nxtbook.com/nxtbooks/scvma/pulse_202104
https://www.nxtbook.com/nxtbooks/scvma/pulse_202103
https://www.nxtbook.com/nxtbooks/scvma/pulse_202102
https://www.nxtbook.com/nxtbooks/scvma/pulse_202101
https://www.nxtbook.com/nxtbooks/scvma/pulse_202012
https://www.nxtbook.com/nxtbooks/scvma/pulse_202011
https://www.nxtbook.com/nxtbooks/scvma/pulse_202010
https://www.nxtbook.com/nxtbooks/scvma/pulse_202009
https://www.nxtbook.com/nxtbooks/scvma/pulse_202008
https://www.nxtbook.com/nxtbooks/scvma/pulse_202007
https://www.nxtbook.com/nxtbooks/scvma/pulse_202006
https://www.nxtbook.com/nxtbooks/scvma/pulse_202005
https://www.nxtbook.com/nxtbooks/scvma/pulse_202004
https://www.nxtbook.com/nxtbooks/scvma/pulse_202003
https://www.nxtbook.com/nxtbooks/scvma/pulse_202002
https://www.nxtbook.com/nxtbooks/scvma/pulse_202001
https://www.nxtbook.com/nxtbooks/scvma/pulse_201912
https://www.nxtbook.com/nxtbooks/scvma/pulse_201911
https://www.nxtbook.com/nxtbooks/scvma/pulse_201910
https://www.nxtbook.com/nxtbooks/scvma/pulse_201909
https://www.nxtbook.com/nxtbooks/scvma/pulse_201908
https://www.nxtbook.com/nxtbooks/scvma/pulse_201907
https://www.nxtbook.com/nxtbooks/scvma/pulse_201906
https://www.nxtbook.com/nxtbooks/scvma/pulse_201905
https://www.nxtbook.com/nxtbooks/scvma/pulse_201904
https://www.nxtbook.com/nxtbooks/scvma/pulse_201903
https://www.nxtbook.com/nxtbooks/scvma/pulse_201902
https://www.nxtbook.com/nxtbooks/scvma/pulse_201901
https://www.nxtbook.com/nxtbooks/scvma/pulse_201812
https://www.nxtbook.com/nxtbooks/scvma/pulse_201811
https://www.nxtbook.com/nxtbooks/scvma/pulse_201810
https://www.nxtbook.com/nxtbooks/scvma/pulse_201809
https://www.nxtbook.com/nxtbooks/scvma/pulse_201808
https://www.nxtbook.com/nxtbooks/scvma/pulse_201807
https://www.nxtbook.com/nxtbooks/scvma/pulse_201806
https://www.nxtbook.com/nxtbooks/scvma/pulse_201805
https://www.nxtbook.com/nxtbooks/scvma/pulse_201804
https://www.nxtbook.com/nxtbooks/scvma/pulse_201803
https://www.nxtbook.com/nxtbooks/scvma/pulse_201802
https://www.nxtbook.com/nxtbooks/scvma/pulse_201801
https://www.nxtbook.com/nxtbooks/scvma/pulse_201712
https://www.nxtbook.com/nxtbooks/scvma/pulse_201711
https://www.nxtbook.com/nxtbooks/scvma/pulse_201710
https://www.nxtbook.com/nxtbooks/scvma/pulse_201709
https://www.nxtbook.com/nxtbooks/scvma/pulse_201708
https://www.nxtbook.com/nxtbooks/scvma/pulse_201707
https://www.nxtbook.com/nxtbooks/scvma/pulse_201706
https://www.nxtbook.com/nxtbooks/scvma/pulse_201705
https://www.nxtbook.com/nxtbooks/scvma/pulse_201704
https://www.nxtbook.com/nxtbooks/scvma/pulse_201703
https://www.nxtbook.com/nxtbooks/scvma/pulse_201702
https://www.nxtbook.com/nxtbooks/scvma/pulse_201701
https://www.nxtbook.com/nxtbooks/scvma/pulse_201612
https://www.nxtbook.com/nxtbooks/scvma/pulse_201611
https://www.nxtbook.com/nxtbooks/scvma/pulse_201610
https://www.nxtbook.com/nxtbooks/scvma/pulse_201609
https://www.nxtbook.com/nxtbooks/scvma/pulse_201608
https://www.nxtbook.com/nxtbooks/scvma/pulse_201606
https://www.nxtbook.com/nxtbooks/scvma/pulse_201605
https://www.nxtbook.com/nxtbooks/scvma/pulse_201604
https://www.nxtbook.com/nxtbooks/scvma/pulse_201603
https://www.nxtbook.com/nxtbooks/scvma/pulse_201602
https://www.nxtbook.com/nxtbooks/scvma/pulse_201601
https://www.nxtbook.com/nxtbooks/scvma/pulse_201512
https://www.nxtbook.com/nxtbooks/scvma/pulse_201511
https://www.nxtbook.com/nxtbooks/scvma/pulse_201510
https://www.nxtbook.com/nxtbooks/scvma/pulse_201509
https://www.nxtbook.com/nxtbooks/scvma/pulse_201508
https://www.nxtbook.com/nxtbooks/scvma/pulse_201507
https://www.nxtbook.com/nxtbooks/scvma/pulse_201506
https://www.nxtbook.com/nxtbooks/scvma/pulse_201505
https://www.nxtbook.com/nxtbooks/scvma/pulse_201504
https://www.nxtbook.com/nxtbooks/scvma/pulse_201503
https://www.nxtbook.com/nxtbooks/scvma/pulse_201502
https://www.nxtbook.com/nxtbooks/scvma/pulse_201501
https://www.nxtbook.com/nxtbooks/scvma/pulse_201412
https://www.nxtbook.com/nxtbooks/scvma/pulse_201411
https://www.nxtbook.com/nxtbooks/scvma/pulse_201410
https://www.nxtbook.com/nxtbooks/scvma/pulse_201409
https://www.nxtbook.com/nxtbooks/scvma/pulse_201408
https://www.nxtbook.com/nxtbooks/scvma/pulse_201407
https://www.nxtbook.com/nxtbooks/scvma/pulse_201406
https://www.nxtbook.com/nxtbooks/scvma/pulse_201405
https://www.nxtbook.com/nxtbooks/scvma/pulse_201404
https://www.nxtbook.com/nxtbooks/scvma/pulse_201403
https://www.nxtbook.com/nxtbooks/scvma/pulse_201402
https://www.nxtbook.com/nxtbooks/scvma/pulse_201401
https://www.nxtbook.com/nxtbooks/scvma/pulse_201312
https://www.nxtbook.com/nxtbooks/scvma/pulse_201311
https://www.nxtbook.com/nxtbooks/scvma/pulse_201310
https://www.nxtbook.com/nxtbooks/scvma/pulse_201309
https://www.nxtbook.com/nxtbooks/scvma/pulse_201308
https://www.nxtbook.com/nxtbooks/scvma/pulse_201307
https://www.nxtbook.com/nxtbooks/scvma/pulse_201306
https://www.nxtbook.com/nxtbooks/scvma/pulse_201305
https://www.nxtbook.com/nxtbooks/scvma/pulse_201304
https://www.nxtbook.com/nxtbooks/scvma/pulse_201303
https://www.nxtbook.com/nxtbooks/scvma/pulse_201302
https://www.nxtbook.com/nxtbooks/scvma/pulse_201301
https://www.nxtbook.com/nxtbooks/scvma/pulse_201212
https://www.nxtbook.com/nxtbooks/scvma/pulse_201211
https://www.nxtbook.com/nxtbooks/scvma/pulse_201210
https://www.nxtbook.com/nxtbooks/scvma/pulse_201209
https://www.nxtbook.com/nxtbooks/scvma/pulse_201208
https://www.nxtbook.com/nxtbooks/scvma/pulse_201207
https://www.nxtbook.com/nxtbooks/scvma/pulse_201206
https://www.nxtbook.com/nxtbooks/scvma/pulse_201205
https://www.nxtbook.com/nxtbooks/scvma/pulse_201204
https://www.nxtbook.com/nxtbooks/scvma/pulse_201203
https://www.nxtbook.com/nxtbooks/scvma/pulse_201202
https://www.nxtbook.com/nxtbooks/scvma/pulse_201201
https://www.nxtbook.com/nxtbooks/scvma/pulse_201112
https://www.nxtbook.com/nxtbooks/scvma/pulse_201111
https://www.nxtbook.com/nxtbooks/scvma/pulse_201110
https://www.nxtbook.com/nxtbooks/scvma/pulse_201109
https://www.nxtbook.com/nxtbooks/scvma/pulse_201108
https://www.nxtbook.com/nxtbooks/scvma/pulse_201107
https://www.nxtbook.com/nxtbooks/scvma/pulse_201106
https://www.nxtbook.com/nxtbooks/scvma/pulse_201105
https://www.nxtbook.com/nxtbooks/scvma/pulse_201104
https://www.nxtbook.com/nxtbooks/scvma/pulse_201103
https://www.nxtbook.com/nxtbooks/scvma/pulse_201102
https://www.nxtbook.com/nxtbooks/scvma/pulse_201101
https://www.nxtbookmedia.com