Magnetics Business & Technology - September/October 2023 - 26

PRODUCT NEWS
Magnetic Liposome Development Service from Creative Biolabs
Structure of magnetic liposome. Image credit: Creative Biolabs.
Methods for targeted drug delivery are being developed actively
in the pharmaceutical industry and liposomes containing magnetic
nanoparticles are a hot topic today. One company serving the
field is Creative Biolabs of Shirley, New York which has created
a comprehensive development platform as a service to formulate
new highly specific liposomes -- including magnetic versions.
Liposomes are molecular-level spheres that can be tailored as
biocompatible vesicles for carrying pharmaceuticals. Supported
by the magnetic field, magnetic liposomes can avoid the reticuloendothelial
system and guide a drug to accurately reach the
target. They have the advantages of reducing the concentration
of free drugs in the blood and reducing adverse drug reactions,
enabling the most critical tumor targeting without damaging
healthy tissues.
With magnetic nanoparticles in them, liposomes can selectively
concentrate in the pathological process area under the action of
external constant magnetic field, and further release drugs under
the action of alternating magnetic field. They can also be used as
magnetic resonance imaging markers and magnetic biosensors.
The biggest advantage liposomes have over other carriers is
that they can be highly functionalized. In recent years, many
new liposome-based drugs have been developed from clinically
approved products to new experimental applications. The major
areas include gene therapy, cancer therapy and mRNA vaccines.
26 Magnetics Business & Technology * September/October 2023
The effectiveness of the release of magnetic liposome encapsulated
substances depends on many factors, explains the company,
including membrane lipid composition, chemical structure
of the drug, field parameters and positioning of the magnetic
nanoparticles. Basically, there are two ways to incorporate them
into liposomes, firstly, into the inner space of the vesicle, and
secondly, into the lipid bilayer. Generally, particles with a hydrophilic
shell are used in the first case, and a carrier stabilized by a
hydrophobic substance is used in the second case. Studies have
shown that compared with vesicles containing magnetic nanoparticles
in the internal aqueous phase, liposomes with magnetic
nanoparticles in the lipid bilayer can release the incorporated
drugs more effectively.
As a pioneer with more than ten years of experience in liposome
development, Creative Biolabs has a team of more than 200
scientists and provides an extensive portfolio of liposome and
lipid products for research, diagnostic and clinical purposes. For
the custom development of magnetic liposomes, their experts
research the physical, chemical and pharmaceutical properties
of magnetic nanoparticles contained in the liposome shell and its
internal space and optimize the performance of the formulation to
meet the needs of different clients.
For more info, see www.creative-biolabs.com.
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Magnetics Business & Technology - September/October 2023

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