Medical Design Briefs - August 2021 - 44

" The e-skin is like human skin - very
stretchable and soft, and sweat can permeate
through it, " Yeon says.
The researchers tested the e-skin by
sticking it to a volunteer's wrist and forehead.
The volunteer wore the tape continuously
over a week. Throughout this
period, the new e-skin reliably measured
his temperature, hydration levels,
UV exposure, and pulse, even during
sweat-inducing activities, such as running
on a treadmill for 30 minutes and
consuming a spicy meal.
The team's design also conformed to
skin, sticking to the volunteer's forehead
as he was asked to frown repeatedly
while sweating profusely, compared
with other e-skin designs that lacked
sweat permeability and easily detached
from the skin.
Kim plans to improve the design's
strength and durability. While the tape
is both permeable to sweat and highly
conformable, thanks to its kirigami patterning,
it's this same patterning, paired
with the tape's ultrathin form, that
makes it quite fragile to friction. As a
result, volunteers had to wear a casing
around the tape to protect it during
activities such as showering.
" Because the e-skin is very soft, it
can be physically damaged, " Yeon says.
" We aim to improve the resilience of
electronic skin. "
This research was supported by
Amorepacific.
This article was written by Jennifer Chu,
MIT. For more information, visit https://
news.mit.edu.
Optical Lens Design Considerations for Cell Imaging in
Microscopy
Understanding application,
use case, and image
resolution are key.
Gray Optics
Portland, ME
In microscopy systems, alignment of
the sample and achieving the highest
image quality are common challenges
that can vary depending on the sample,
i.e., what is to be imaged and at what
length scale. In modern cell analysis
instruments, a custom lens design is often
deployed to achieve optimal imaging performance
and to control costs. When
considering a custom lens design understanding
the application, use case, and
image resolution needed are key aspects
to consider in achieving the required performance.
This article covers the key considerations
involved in specifying and
developing optical imaging objectives
and considers two common use cases.
Microscopes for cell imaging (e.g.,
spatial genomics, high-content screening,
digital pathology, as examples of
" microscopes in a box " ) operate under
the principle of optical magnification,
often referred to as optical power. Prior to
the advent of digital imaging, most
microscopes were built for general purpose
use, with reconfigurable objective
lenses and spectral filters, providing different
degrees of magnification. Ap -
plications requiring additional contrast
using fluorescence dyes add more complexity
to the microscope system. Today,
the high performance offered by general
purpose instruments can now be
achieved in a compact low-cost format
suitable for new product introductions.
44
Intro
Cov
Fig. 1 - Example of a micro custom lens. This is an example of an infinity corrected lens for high
magnification microscopy. When matched with a tube lens to form an image on the image sensor,
the resulting magnification will be 10x.
Fig. 2 - Example of a point-to-point macro lens design. The object plane is on the left and image plane
on the right and the magnification is 0.75x, meaning the image is smaller than the object.
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