Medical Design Briefs - August 2021 - 9

change cross sections. It leverages the
green strength of HCR silicone and
eliminates assembled joints that can be
weak and cause failure modes and internal
misalignments, increasing component
strength, longevity, and robustness.
Silicone is one of the most successful
materials in the design and production
of combination products, in particular,
implantable devices. Due to the material's
favorable porous nature, an API
can be integrated into a silicone
matrix, enabling drugs to be eluted
into the human body at specific doses
over time.
Two methods exist for adding APIs
to silicone for drug-delivery devices.
The established method is the addition
of an API to raw silicone. An alternative
and more recent development is the
impregnation of an API into vulcanized
silicone by immersion. The advantages
of this method are twofold: the
API does not interfere with the cure
chemistry of the silicone, and the API
is uniformly impregnated throughout
the component.
Conclusion
Responding to rapid growth in the
medical device market, medical
device manufacturers are looking to
new and innovative processes, including
miniaturization and wearability,
to enhance their products and meet
patients' needs.
Advances in hose and tubing manufacturing
techniques are helping to
support these new developments and
improve patients' quality of life with
better function and integrity, and by
enabling the incorporation of APIs.
To facilitate the specification of these
seemingly uncomplicated yet complex
extrusions, it is important to work with
an expert in hoses and tubing who will
consider the key factors relevant to the
application and can employ progressive
technologies and processes to revolutionize
the medical device design.
This article was written by Dan Sanchez,
Product Manager Manufacturing, Trelleborg
Healthcare & Medical, Fort Wayne, IN.
For more information, visit http://info.
hotims.com/79416-340. For more information
on tubing technologies and application
examples, download the Advanced Extru -
sion Techniques whitepaper by Trelleborg
Healthcare & Medical at https://www.
trelleborg.com/en/healthcare/toolsand-media/technical-library/advancedextrusion-
whitepaper.
Medical Design Briefs, August 2021
Intro
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ToC
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http://info.hotims.com/79416-761 http://info.hotims.com/79416-340 https://www.trelleborg.com/en/healthcare/tools-and-media/technical-library/advanced-extrusion-whitepaper

Medical Design Briefs - August 2021

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