Medical Design Briefs - September 2021 - 38

Bioprinted 3D Cardiac Patches Could Reverse Scar
Formation After Heart Attacks
The system promotes myocardial
regeneration after a cardiac event.
AIP Publishing
Washington, DC
Cardiovascular diseases account for 32 percent of
global deaths. Myocardial infarction, or heart attacks,
play a large part in heart diseases and the necrosis of cardiac
tissue after blood supply is decreased or stopped.
In APL Bioengineering, re searchers from Pohang
University of Science and Technology in South Korea
take stock of stem cell-laden 3D bioprinted cardiac
patch technologies and their efficacy as a therapeutic
and regenerative approach for ischemic cardiomyopathy
in reversing scar formation and promoting myocardial
regeneration.
Bioink I
Bioink II
with
Cardiac progenitor cells
(CPCs)
Mesenchymal stem cells
(MSCs)
Ink I
Ink II
vascular
endothelial
growth
factors
" Currently available therapeutics are not sufficient
for the complete treatment of myocardial infarction, "
says author Jinah Jang. " The development of a new,
advanced modality, such as reducing adverse cardiac
remodeling, promoting myocardial functions, and correcting
molecular or genetic defects, is urgently required. "
The researchers explore various types of candidate stem
cells that possess cardiac regenerative potential, explaining
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Schematic illustration of a pre-vascularized stem cell patch having multiple stem cellladen
bioinks. (Credit: Jinah Jang, Reprinted from Biomaterials, Vol 112, Jinah Jang
et al., 3D printed complex tissue construct using stem cell-laden decellularized extracellular
matrix bioinks for cardiac repair, Pages 264-274, Copyright (2017), with
permission from Elsevier.)
their applications and limitations. They share updates on the
challenging implementation of the state-of-the-art 3D bioprinting
approach to fabricate a cardiac patch and highlight
different strategies to implement vascularization and augment
cardiac functional properties with respect to electrophysiological
similarities to native tissue.
Following a myocardial infarction, myocardial tissues and
vasculatures are equally and severely damaged. Therefore,
therapeutic or regenerative approaches should be planned to
target both of them concurrently to achieve a successful cardiac
repair, because the heart has very little ability to regenerate
cardiomyocytes or heart cells by itself.
Employing a 3D bioprinting strategy to geometrically control
the spatial patterning and using dual stem cell therapy as
its co-culture can play an important role in promoting and
synergistically improving vascularization as well as cardiac
function following myocardial infarction.
Currently applied patch-based stem cell therapies have
shown advanced efficacy, rather than using single-component
therapies, by providing a tissue-friendly environment during
the time of host-graft integration.
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Intro
Cov
ToC
+
-
A
" It would be helpful for tracing cells of the printed patch
to investigate the mode of action for the transplanted patch, "
says author Sanskrita Das.
" Although there are still inherent limitations for the clinical
study, the suggested stem cell delivery platform technology
provides a practical therapeutic perspective for various
tissue engineering applications, " says author Hyoryung
Nam.
As enthusiasm for cardiac regeneration charges and science
continues to advance, 3D bioprinted cardiac patches
will soon become an increasingly feasible, viable, and functional
option, unblocking the barriers to achieve cardiomyocytes
properties. This will open new avenues for cardiac
research, paving the way for new treatments for patients with
cardiovascular disease.
For more information, visit https://publishing.aip.org.
.
Medical Design Briefs, September 2021
µ
MSC + VEGF
CPCs
CPCs
CPCs
MSC + VEGF
È

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Medical Design Briefs - September 2021

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