Medical Design Briefs - April 2023 - 30

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as it heals, it should dry up. Moisture alters
the current, so we are able to detect
that by tracking electrical resistance in
the wound. Then, we can collect that information
and transmit it wirelessly.
With wound care management, we ideally
want the wound to close within a
month. If it takes longer, that delay can
raise concerns. "
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In a study of animal models, the researchers
applied electrical stimulation for
just 30 minutes a day. Even this short
amount of time accelerated the closure by
30 percent.
n Disappearing Act
When the wound is healed, the flowershaped
electrode simply dissolves into the
body, bypassing the need to retrieve it. The
team made the electrodes from a metal
called molybdenum, which is widely
used in electronic and semiconductor
applications. They discovered that when
molybdenum is thin enough, it can biodegrade.
Furthermore, it does not interfere
with the healing process.
" We are the first to show that molybdenum
can be used as a biodegradable
electrode for wound healing, " Ameer
says. " After about six months, most of it
was gone. And we found there's very little
accumulation in the organs. Nothing
out of the ordinary. But the amount of
metal we use to make these electrodes is
so minimal, we don't expect it to cause
any major issues. "
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Next, the team plans to test their bandage
for diabetic ulcers in a larger animal
model. Then, they aim to test it on
humans. Because the bandage leverages
the body's own healing power without
releasing drugs or biologics, it faces fewer
regulatory hurdles. This means patients
potentially could see it on the market
much sooner.
MAY 2-4, 2023
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The study, " Bioresorbable, wireless
battery-free system for electrotherapy
and impedance sensing at wound sites, "
was partially supported by the National
Institute of Diabetes and Digestive and
Kidney Diseases and CARE. Northwestern
biomedical engineering
doctoral
rapid3devent.com
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3/2/23 10:36 AM3/2/23 1:31 AM
candidate Joseph Song is co-first author.
Contact: John Rogers, Louis Simpson
and Kimberly Querrey Professor of Materials
Science and Engineering, Biomedical
Engineering and Neurological
Surgery, jrogers@northwestern.edu. For
more information, visit https://news.
northwestern.edu.
Medical Design Briefs, April 2023
http://rapid3devent.com https://news.northwestern.edu http://www.medicaldesignbriefs.com
Medical Design Briefs - April 2023

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