Medical Design Briefs - May 2023 - 21

n Artificial Enzyme
Offers Fast Detection of
Disease-Related
Hormone
n Nano-Sized Sensor Detects
Protein Biomarkers
Researchers have devised a tiny,
A handheld sensor tests
perspiration for cortisol and
provides
results
A handheld sensor tests perspiration for
cortisol. (Credit: Johanna Carson)
in
eight
minutes, which researchers
say is a key advance in monitoring
a hormone whose levels
are a marker for many illnesses, including various cancers.
The material and sensing mechanism in the device could be
easily engineered to detect other specific hormones, such as
progesterone, a key marker for women's reproductive health
and pregnancy outcomes.
The enzyme mimic sensor avoids the most expensive and
time-consuming elements of conventional cortisol testing. The
sensor is naturally enzyme free, label free, and redox signaling
probe free. The integrated sensor can be applied to point-ofcare
and wearable applications.
The artificial enzyme is a special polymer with tiny spaces
shaped to fit only cortisol molecules. These spaces are surrounded
by catalysts that make cortisol react, producing electrical
signals. By measuring the signals, the amount of cortisol
present can be determined, an important diagnostic tool.
For more information, visit www.medicaldesignbriefs.com/
roundup/0523/hormone.
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* Accuracy 1.5%
* Sensor output is I2C
* Connections are Male/Female Luer
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Medical Design Briefs, May 2023
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21
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designs, produces, and sells an extensive range
of flow, bubble, pressure, load cell, and liquid
level sensors for a variety of applications.
STRAIN MEASUREMENT
DEVICES
Three distinct protein binders
attached to the same
nanopore. (Credit: Mohammad
Ahmad)
nano- sized sensor capable of detecting
protein biomarkers in a sample at
single-molecule precision. Coined as
hook and bait, a tiny protein binder
fuses to a small hole created in the
membrane of a cell - known as a
nanopore - which allows ionic solution
to flow through it.
When the sensor recognizes a targeted
molecule, the ionic flow
changes. This change in flow serves
as the signal from the sensor that the biomarker has been
found. The sensor design architecture can be applied to a
broad range of protein targets.
The team coupled nanopore technology with antibody mimetic
technology - artificially designed protein scaffolds that bind and
interact with a specific biomarker and behave like antibodies. To
validate their findings, the team tested their hypothesis using a
blood serum sample. They were able to identify and quantify epidermal
growth factor receptor (EGFR), a protein biomarker in
various cancers. In addition, numerous calibrations of the sensors
were conducted using other biophysical techniques.
For more information, visit www.medicaldesignbriefs.com/
roundup/0523/biomarkers.
http://www.medicaldesignbriefs.com/roundup/0523/hormone http://www.medicaldesignbriefs.com/roundup/0523/biomarkers http://info.hotims.com/84479-733 http://www.medicaldesignbriefs.com
Medical Design Briefs - May 2023

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