Medical Design Briefs - August 2023 - 10

Surface Modification:
Improving Well Plates for
Drug Discovery
E
10
ach year, billions of well plates are manufactured
for research, drug discovery, and diagnostic testing.
Although many are inexpensive consumables, an
increasing percentage require more sophisticated
surface modification and functional coatings from
labware manufacturers. This surface modification aims to improve
the adhesion or proliferation of antibodies, proteins,
cells, and tissue and improve the signal-to-noise ratio for highresolution
testing with less target material or markers required.
Unfortunately, there are limitations to this approach. Precoated
well plates are expensive, and the functional coatings
may only suffice for more straightforward research or testing
requirements. A more customized solution is often required
for cutting-edge R&D for drug discovery and diagnostic test
development.
When this is the case, an increasingly popular alternative
is contract services that can apply functional coatings optimized
explicitly for the application. In this arrangement, inexpensive,
uncoated labware is purchased and delivered to
the contract service provider for plasma treatment. Surprisingly,
this approach often lowers coated labware costs while
providing high-quality standards. The savings can increase at
higher production volumes, given the contract service providers'
ability to scale up and move to higher-capacity plasma
treatment tools.
Plasma Treating Well Plates
Well plates are a standard tool in analytical research and clinical
diagnostic testing laboratories. The wells that function as
small test tubes are used to perform many tests at a time while
keeping the test environment the same.
Well plates are manufactured using polystyrene primarily
because the material is stable and allows for the long-term
containment of chemical compounds. It is biologically inwww.medicaldesignbriefs.com
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Medical Design Briefs - August 2023

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Medical Design Briefs - August 2023 - COV1a
Medical Design Briefs - August 2023 - COV1b
Medical Design Briefs - August 2023 - COV1
Medical Design Briefs - August 2023 - COV2
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