Medical Design Briefs - August 2023 - 20

OPTICALLY CLEAR EPOXY
PASSES
STANDARD FOR
CYTOTOXICITY
ed
Microneedles
cations of antibiotics may reduce the sensitivity of bacteria to
drugs. Patients who have been affected by acne for a long time
know that the beneficial effects of the same treatment products
can be significantly reduced after long-term use.
Research Method and Findings
EASY TO USE MIX RATIO
Two to one by weight
FAST CURING
Even in thin sections
OPTICALLY CLEAR
Non-yellowing properties
LOW VISCOSITY
Ideal for potting & encapsulation
The microneedle patch facilitates the transdermal delivery of
ultrasound-responsive antibacterial nanoparticles to treat the infection
induced by P. acnes using a minimally invasive approach.
In the current design, ultrasound-responsive antibacterial nanomaterials
are introduced to the microneedle patch, which responds
to bacterial infection quickly and efficiently. The use of
drugs is avoided in the treatment of acne.
The modified nanoparticles comprised of ZnTCPP and ZnO
can produce a substantial amount of reactive oxygen species
(ROS) subject to ultrasound stimulation, which can effectively
oxidize the key cellular macromolecules of bacteria. The results
demonstrate that the killing of P. acnes bacteria mediated by ROS
can reach to 99.73 percent after 15 minutes of ultrasound stimulation.
Also, the levels of inflammatory markers, including tumor
necrosis factor-a (TNF-α), interleukins (ILs), and matrix metalloproteinases
(MMPs) are significantly reduced. Furthermore, the
zinc ions released can elevate the DNA replication-related genes,
thereby augmenting more fibroblasts toward superior skin repair.
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20
" The new microneedle patch enabling ROS generation
upon ultrasound stimulation, regarding as a nonantibiotic and
transdermal approach, can not only effectively address the infection
induced by P. acnes bacteria, but also facilitates the skin
repair due to zinc ion release, " says Prof. Wai-kwok. " Due to the
specific killing mechanism of ROS, we believe that this design
is also able to address other skin infections induced by fungi,
parasites, or viruses, such as tinea pedis (known commonly as
Athlete's Foot or Hong Kong Foot). "
This research study was led by Prof. Yeung. The first author,
Xiang Yiming, is the PhD candidate under Prof. Yeung's supervision.
This
work was jointly supported by the National Key R&D Programmes
of China (2018YFA0703100), the General Research
Fund of Hong Kong Research Grants Council (Nos. 17207719 and
17214516), the Health Bureau Health and Medical Research Fund
(Nos.19180712, 20190422 and 21200592), the Innovation and Technology
Fund Partnership Research Programme (PRP/030/30FX),
the National Science Fund for Distinguished Youth Scholars (No.
51925104), Shenzhen Science and Technology Programme (Nos.
JSGG20180507183242702 and JCYJ20210324120009026), and the
Shenzhen's Sanming Project of Medicine - 'Team of Excellence in
Spinal Deformities and Spinal Degeneration' (SZSM201612055).
Reference
1. Lee, Y.B.; Byun, E.J.; Kim, H.S. Potential Role of the Microbiome in Acne: A
Comprehensive Review. Journal of Clinical Medicine, Vol8(7), pp 987, June 2019.
https://doi.org/10.3390/jcm8070987.
For more information, contact Prof. Kelvin Yeung Wai-kwok
via e-mail at wkkyeung@hku.hk or visit https://hku.hk.
Read the full scientific paper.
www.medicaldesignbriefs.com
7/18/23 5:20 PM
Medical Design Briefs, August 2023
http://info.hotims.com/84482-810 https://doi.org/10.3390/jcm8070987 http://www.techbriefs.com/webinar362 https://hku.hk http://www.medicaldesignbriefs.com
Medical Design Briefs - August 2023

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