August 2023 Published by SAE Media Group® n COLUMNS 2 From the Editor 3 Q&A: Wearable Injectors and Connected Devices for Drug Delivery n FEATURES 6 Manufacturing Considerations for Implantable Drug-Delivery Systems 10 Surface Modification: Improving Well Plates for Drug Discovery 14 How Nature Inspires the Future of Health n ADVANCED TECHNOLOGIES 18 Robotic Pill Safely Delivers Injectable Osteoporosis Drug 19 Novel Microneedle Array Enables Breakthrough Treatment 21 'Smart' Sutures Deliver Drugs and Sense Inflammation 23 Implantable Drug-Delivery System Powered by Light 24 FDA Clears Bionic Pancreas for People with Type 1 Diabetes 25 New Drug-Delivery Method Reverses Senescence of Stem Cells 27 Novel Drug-Delivery Development Center Opens in UK INTROTEK.qxp_1/2 Page Horizontal 1/14/20 3:35 PM Page 1 n ON THE COVER Researchers have succeeded in designing synthetic DNA that controls the cells' protein production. The technology can contribute to the development and production of vaccines and drugs for severe diseases, as well as alternative food proteins much faster and at significantly lower costs than today. How genes are expressed is a process that is fundamental to the functionality of cells in all living organisms. Simply put, the genetic code in DNA is transcribed to (mRNA), which the tells molecule the cell's factory messenger which RNA protein to produce and in which quantities. Read the article on page 28 to learn the principle behind the new method. The cover image shows a close-up AI-generated photograph of a researcher's hand holding a pipette, dispensing a DNA solution into a test tube. (Credit: Oleksandr/AdobeStock) 28 AI Tailors DNA for Future Drug Development 29 New AI Model Offers Way to Speed Up Drug Discovery 31 RFID Labels Enhance Tracking of Prefilled Syringes n DEPARTMENTS 32 Advertisers Index WHEN CONTACT IS NOT AN OPTION: Introtek - The Trusted Source for Non-Invasive Medical Sensor Solutions. Drip Chamber Liquid Level & Drip Detect Sensors Air Bubble & Air-in-Line Sensors Blood Component Sensors IntroPro™ IntroFlow™ - Occlusion Sensors Flow Sensors Continuous & Single Point Level Sensors Introtek International * 150 Executive Drive Edgewood, NY 11717 * Ph: 631.242.5425 introtek.com II MDB Introtek Ad 0223.indd 1 www.medicaldesignbriefs.com Medical Design Briefs, August 2023 1/12/23 5:33 PMhttp://info.hotims.com/84482-804 http://www.medicaldesignbriefs.com