Medical Design Briefs - October 2023 - 18

OPO Lasers Spur Advances in
Mass Spectrometry Diagnostics
M
ass spectrometry (MS), which is used to identify
molecules within a sample by measuring the
mass-to-charge ratio of ions, is employed across
many fields of study, including biology, chemistry,
physics, and clinical medicine. As the technology
continues to evolve, so will the applications that can
benefit from this important tool.
One field that is truly seeing the benefits of MS innovation
is in medical research and diagnostics. Currently, MS is used in
a lab setting to analyze samples containing biomolecular species
such as peptides and proteins in tissue, bacteria, and cells.
Information related to a sample's composition of abundant
and, in some cases, trace biomolecules can be obtained. Advances
in micropositioning equipment and large digital storage
arrays have spurred advances in MS imaging (MSI), which
produces detailed maps of biomolecule distribution in tissue.
However, new methodologies that allow direct analysis in real
time within the sample's native environment means samples
no longer need to be sent to a lab and can provide
medical personnel with fast answers during critical
surgical procedures.
The Evolution of Mass Spectrometry
To understand the progress toward real-time MS analyses, a
brief background summary of how MS works using different
desorption/ionization techniques as they pertain to liquid and
solid samples is helpful. Typically, sample material is desorbed
into the gas phase and ionized in a one-step process, then the
subsequently produced ions are accelerated through an electric
and/or magnetic field, affecting speed and trajectory. Ions
will change trajectory at varying magnitudes depending on
their mass-to-charge ratio. The differences in mass-to-charge
ratio allow a mass analyzer to sort the ions, then produce
a result that notes the relative abundance of the detected
ions (based on the mass-to-charge ratio). CompoAt
the core of this new methodology are fast-pulsed, mid-IR
lasers that are capable of desorbing and/or ionizing sample
material with little to no sample preparation. Combined with
other techniques for transporting sample material and improving
ionization efficiency, these lasers provide mass spectrometry
equipment OEMs with a powerful component in a much
smaller package and lower cost than previous alternatives.
The inherent focusability of
lasers are also capable of sampling
incredibly small size areas
measured in tens of micrometers,
a key benefit for MS imaging.
(Credit: OPOTEK)
18
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Medical Design Briefs - October 2023

Table of Contents for the Digital Edition of Medical Design Briefs - October 2023

Medical Design Briefs - October 2023 - CV1a
Medical Design Briefs - October 2023 - CV1b
Medical Design Briefs - October 2023 - Cov1
Medical Design Briefs - October 2023 - Cov2
Medical Design Briefs - October 2023 - 1
Medical Design Briefs - October 2023 - 2
Medical Design Briefs - October 2023 - 3
Medical Design Briefs - October 2023 - 4
Medical Design Briefs - October 2023 - 5
Medical Design Briefs - October 2023 - 6
Medical Design Briefs - October 2023 - 7
Medical Design Briefs - October 2023 - 8
Medical Design Briefs - October 2023 - 9
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Medical Design Briefs - October 2023 - Cov3
Medical Design Briefs - October 2023 - Cov4
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