Medical Design Briefs - October 2023 - 46

n Wireless Device Enables
Catheter-Free Bladder
Pressure Monitoring
A wireless device called the
UroMonitor enables accurate,
noninvasive monitoring of bladder
pressure in patients with
overactive bladder. It is the first
device to enable catheter-free
telemetric ambulatory bladder
pressure monitoring in humans.
n Novel BiosensingMembrane
for Glucose
Detection and Monitoring
Inspired by the structure of
electron-transfer chains in
the mitochondria, a research
group has developed a 3D mesoporous
biosensing- membrane
with neighborhood nanostructures
that shows excellent sensitivity
and long-term stability.
The UroMonitor was developed as a noninvasive approach
for assessing function of the lower urinary tract, without the
need for catheter placement. The UroMonitor is a small, flexible
device - no more than 2 in. across - that is placed into
the patient's bladder. Once in place, the device wirelessly transmits
bladder pressure data to a small radio receiver taped to
the lower abdomen.
In a pilot study to evaluate clinical safety and accuracy, the researchers
tested the UroMonitor in 11 women (median age 67
years) with symptoms of overactive bladder. After the patients underwent
initial urodynamic testing, the UroMonitor device was
inserted into the bladder via the urethra. Urodynamic testing was
then repeated, with simultaneous transmission of bladder pressure
data. (Image credit: Journal of Urology)
For more information, visit www.medicaldesignbriefs.com/
roundup/1023/bladder.
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In preparing the biosensing-membranes, the researchers
used tannic acid-3-aminopropyltriethoxysilane-Fe3+ (TA-APTES-Fe)
ternary coating to properly assemble and adjacently
confine Prussian blue (PB) and GOx in the 3D mesoporous
carbon nanotube (CNT) membrane electrode.
The spatially confined microenvironment stabilizes PB
and GOx. The separation function of the CNT membrane
further intensifies the sensing stability by in-situ removal of
interferents from the analytes. The as-prepared mesoporous
biosensing-membrane exhibits good sensitivity and longterm
stability with a negligible response drift for up to eight
hours, thus outperforming the reported results. (Image
credit: Zhang Hao)
For more information, visit www.medicaldesignbriefs.com/
roundup/1023/glucose.
n Device Helps
Prevent Complication
During Common
Heart Procedure
For some with AFib, a
catheter ablation is used
to burn or freeze the
precise area causing the problem to restore a normal heart
rhythm. While this method is effective, the energy from the
catheter tip can cause serious damage to the adjacent esophagus,
which is only a few millimeters away. It's an injury that can
be life threatening, so an electrophysiologist has helped develop
a new device that gently diverts the esophagus out of harm's
way, greatly improving safety.
Pulling in the esophagus using suction force and then
moving the entire segment to the side by about an inch creates
a safe pathway to deliver the energy to treat AFib. A clinical
trial found that without the device, over a third of heart
ablation patients had esophageal injuries, but when the new
device was used, less than 5 percent of patients had any injury
to the esophagus, and they were much less severe than the
control group.
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46
There have been attempts to protect the esophagus during
heart ablations in the past using different techniques like measuring
the temperature inside the esophagus, using ultrasound
imaging to identify where it's located, and using shorter or less
intense ablation energy, but esophageal injury continued to be
a serious problem. The researchers say this device ensures that
patients are getting the safest procedure possible without compromising
any benefits to their heart. (Image credit: The Ohio
State University)
For more information, visit www.medicaldesignbriefs.com/
roundup/1023/heart.
www.medicaldesignbriefs.com
Medical Design Briefs, October 2023

http://www.medicaldesignbriefs.com/roundup/1023/glucose http://www.medicaldesignbriefs.com/roundup/1023/bladder http://www.medicaldesignbriefs.com/roundup/1023/glucose http://www.medicaldesignbriefs.com/roundup/1023/bladder http://info.hotims.com/84484-799 http://www.medicaldesignbriefs.com/roundup/1023/heart http://www.medicaldesignbriefs.com/roundup/1023/heart http://www.medicaldesignbriefs.com

Medical Design Briefs - October 2023

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