Medical Design Briefs - October 2024 - 49

MDB Statek Ad 0621.qxp_1/3 Page Vertical 5/26/21 12:21 PM
map that back to blood pressure, and, significantly,
how to build a working system.
" Building that system required some
extraordinarily bespoke technologies, "
says Rajagopal. Caltech alumnus Raymond
Jimenez (BS '13) was instrumental
in building out that first system. " The art
form, which involved a lot of other Caltech
alumni, was to put the physics answer into
a very simple, practical instrument. "
The resulting Esperto device is small,
noninvasive, and relatively inexpensive,
and it has an automated method for locating
the patient's blood vessel without
needing to be physically repositioned. It
also does not suffer from the problems
that some blood pressure monitoring
devices have, such as not being accurate
for patients with low blood pressure or
getting varying results depending on a patient's
skin tone.
It might not be a medical tricorder, but
the team says the device solves the longstanding
blood pressure monitoring problem.
And Rajagopal says it is the product
of a million small leaps. " Everything we've
done is a product of the exact mistakes
we've made over time, " he says, " and all
the work that others have done too. "
" This work is emblematic of what makes
Caltech so remarkable: solving a very hard
problem by going back to first principles
and understanding a physical phenomenon
at the fundamental level, " says Fred
Farina, Caltech's chief innovation and
corporate partnerships officer. " This approach,
combined with the tenacity and
entrepreneurial drive of the team, is our
homemade recipe for societal impact and
improving people's lives. "
The paper describing the new technique
is titled, " Resonance sonomanometry
for noninvasive, continuous monitoring
of blood pressure. " Additional authors
on the paper include Raymond Jimenez
(BS '13), Steven Dell, Austin C. Rutledge,
Matt K. Fu (BS '13), and William
P. Dempsey (PhD '12) of Esperto Medical,
and Dominic Yurk (BS '17, PhD '23), a
current member of Abu-Mostafa's group
at Caltech. The work at Caltech was supported
by Caltech trustee Charles Trimble
(BS '63, MS '64), the Carver Mead Innovation
Fund, and the Grubstake Fund.
This article was written by Kimm
Fesenmaier, Caltech. For more information,
contact kfesenma@caltech.edu or
visit www.caltech.edu.
Wearable, Stretchable Sensor
Detects Solid-State Skin Biomarkers
The novel sensor
accurately measures
markers such as
cholesterol and lactate.
National University of
Singapore, Singapore
Detecting diseases early requires the
rapid, continuous and convenient monitoring
of vital biomarkers. Researchers
from the National University of Singapore
(NUS) and the Agency for Science,
Technology and Research (A*STAR)
have developed a novel sensor that enables
the continuous, and real-time
detection of solid-state epidermal biomarkers
(SEB), a new category of health
indicators.
Jointly led by Liu Yuxin, assistant professor
from the NUS Institute for Health
Innovation & Technology, as well as N.1
Institute for Health and the department
Medical Design Briefs, October 2024
Ultra-Miniature - High Reliability
Quartz Crystals, Oscillators
and Sensors
UNSURPASSED QUALITY
THE MEDICAL INDUSTRY
COUNTS ON
UNSURPASSED QUALITY
THE MEDICAL INDUSTRY
COUNTS ON
of biomedical engineering under the
NUS College of Design and Engineering,
and Dr. Yang Le, principal scientist
and head of the sensors and flexible
electronics department of A*STAR's Institute
of Materials Research and Engineering
(A*STAR's IMRE), the research
team's innovation offers a noninvasive
method to monitor health by detecting
biomarkers such as cholesterol and lactate
- directly on the skin.
The team's wearable, stretchable,
hydrogel- based sensor overcomes the
limitations of current methods that rely
on biofluid samples, such as blood, urine
and sweat. This makes it a promising alternative
for wearable, continuous, and
real-time health monitoring, facilitating
the early detection of conditions such as
cardiovascular diseases and stroke. It can
also efficiently monitor athletes' lactate levels,
an indication of exhaustion and tissue
hypoxia, which affect their performance.
This development is especially pertinent
www.medicaldesignbriefs.com
Medical Grade Crystals,
Oscillators and Sensors
* High stability and precision
* Used in implantable devices
* Excellent long term aging
* Low power consumption
STATEK CORPORATION
ISO 9001
AS9100
512 N. Main St., Orange, CA 92868
Tel. 714-639-7810
Fax 714-997-1256
www.STATEK.com
49
http://info.hotims.com/86260-750 http://info.hotims.com/86260-750 http://www.caltech.edu https://www.medicaldesignbriefs.com
Medical Design Briefs - October 2024

Table of Contents for the Digital Edition of Medical Design Briefs - October 2024
