Medical Design Briefs - October 2024 - 51

" This wearable sensor is the first-in-the-world that can
monitor biomarkers on dry or non-sweaty skin. The sensor's
novel bilayer hydrogel electrode interacts with and detects
biomarkers on our skin, allowing them to become a new class
of health indicators. The stretchable design enhances comfort
and accuracy as well, by adapting to our skin's natural
elasticity. This innovation can change the way we approach
health and lifestyle monitoring, particularly for those living
with chronic conditions requiring constant health monitoring, "
says Dr. Yang.
n Reliable, Sensitive, and User-Friendly
Unlike traditional sensors that require biofluid samples, this
sensor can continuously and noninvasively monitor SEBs directly
on the skin, making it valuable for remote patient monitoring
and population-wide health screening.
In clinical studies, the sensor demonstrated strong correlations
between the biomarkers detected on the skin and
those found in blood samples. This validates the sensor's accuracy
and reliability, suggesting it could be an alternative to
blood tests for monitoring chronic diseases such as diabetes,
hyperlipo proteinemia, and cardiovascular conditions.
The sensor's sensitivity is another advantage, as it can detect
solid-state lactate and cholesterol at very low levels. This level of
sensitivity approaches that of mass spectrometry, which ensures
precise monitoring of these biomarkers.
Additionally, the sensor's design reduces motion artifacts,
which occur when the user's movements affect the placement
of the sensor or its contact pressure to the skin, by three times
compared to conventional counterparts. This new finding was
successfully modeled mathematically. By minimizing disruptions
caused by movement, the bilayer hydrogel ensures consistent
and reliable readings, while the stretchable, skin-like
nature of the device enhances user comfort.
" One of the possible applications of this technology is to
replace the pregnancy diabetic test, commonly known as the
glucose tolerance test. Rather than subject pregnant women
to multiple blood draws, our sensor could be used to track
real-time sugar levels conveniently in patients' home, with a
similar level of accuracy as traditional tests. This also can be
applied to diabetes in general, replacing the need for regular
finger-prick test, " Liu says.
" Another potential application is to use the sensor in the daily
monitoring of heart health, as cardiovascular disease accounts for
almost one-third of deaths in Singapore. The research team has
embarked on a research program to work closely with cardiologists
in establishing clinical correlation between biomarkers - lactate,
cholesterol, and glucose - with heart health, " says Dr. Yang.
n Rolling Out Next-Gen Sensors
The NUS and A*STAR researchers plan to enhance the sensor's
performance by increasing its working time and sensitivity.
Further, they aim to integrate additional solid-state analytes,
broadening the sensor's applicability to other biomarkers. The
researchers are also collaborating with hospitals to provide
additional clinical validation and bring the technology to patients,
particularly for continuous glucose monitoring, as well
as quantitative assessment of dynamic resilience.
For more information, contact Dr. Liu Yuxin at lyx@nus.
edu.sg or visit https://news.nus.edu.sg.
Medical Design Briefs, October 2024
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Medical Design Briefs - October 2024

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