Medical Design Briefs - January 2025 - 25

Hourglass-Shaped Stent Could Ease Severe Chest Pain
from Microvascular Disease
The hourglass shape
improves blood flow.
Mayo Clinic, Rochester, MN
Microvascular disease is a condition
in which tiny blood vessels in the heart
are not working properly, resulting in
reduced blood flow to the heart. The
A study at Mayo Clinic suggests that
an hourglass-shaped stent could improve
blood flow and ease severe and reoccurring
chest pain in people with microvascular
disease. Of 30 participants in a phase 2
clinical trial, 76 percent saw improvement
in their day-to-day life. For example, some
participants who reported not being able
to walk around the block or up a flight
of stairs without chest pain were able to
do these ordinary physical activities at the
end of a 120-day period.
Clinical measures of blood flow related
to the microvasculature of the
heart significantly improved during follow-up,
according to findings published
in the Journal of the American College of
Cardiology: Cardiovascular Interventions.
resulting chest pains, or angina, can be
debilitating, limiting a person's ability to
exercise, do household chores or even
walk to the mailbox. About 40 percent of
patients receiving a diagnostic coronary
angiogram for chest pain do not have
blocked arteries that also can cause angina.
However, up to 66 percent of these
patients do have coronary microvascular
disease, which is more common in
women overall and found in people with
conditions such as diabetes, high blood
pressure, and obesity.
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For decades, there have been few
viable treatment options to improve
blood flow through the tiny vessels of
the heart. At most, doctors have treated
symptoms of angina with several
medications and cardiovascular disease
prevention methods, including
healthy eating, weight loss, and regular
exercise. The use of a stent could
target the issue behind the chest pain
- the severe reduction in blood flow
affecting the heart muscle.
Unlike tube-shaped stents used to
open clogged arteries, the hourglassshaped
stent narrows in the middle.
The different design is thought to increase
back pressure, redistributing
blood flow more fully through small
vessels in the heart that were not working
at capacity.
" The
patients with
heart-related
micro vascular dysfunction in this
study had little ability to control their
chronic angina, which severely limited
their day-to-day activities, " says Amir
Lerman, MD, a cardiologist at Mayo
Clinic and senior author of the study.
" Beyond reductions in chest pain
and being able to comfortably handle
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Medical Design Briefs - January 2025

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