Medical Design Briefs - January 2025 - 30

nals (i.e., electrical, optical, thermal,
etc.) to neurons and other types of cells
in a minimal or noninvasive manner. Although
preliminary, the cytocompatibility
data reported in this work is also very
promising for future use in vivo, " says
Flavia Vitale, associate professor of neurology,
bioengineering, and physical
medicine and rehabilitation at the University
of Pennsylvania, who was not involved
with this work.
The research was supported by the
Swiss National Science Foundation and
the U.S. National Institutes of Health
Brain Initiative. This work was carried
out, in part, through the use of MIT
nano facilities.
This article was written by Adam Zewe,
MIT News. For more information, contact
Deblina Sarkar, PhD, at deblina@
mit.edu or visit https://news.mit.edu.
Researchers Develop Wireless Brain Neural
Signal Recorder
The device paves the way
for treating brain diseases
such as Parkinson's.
DGIST
Daegu, Republic of Korea
Researchers have developed a fully embedded
wireless brain neural signal recorder.
The device was created by Prof. Jang
Kyung-in of the department of robotics
and mechanical electronics at DGIST in
collaboration with a research team led by
Fully implantable neural interface
Litz
coil
Bridge
rectifier
Accelerometer
Biopotential
amp
SPI slave
32 inputs
Voltage
regulator
BLE MCU
ADC
GPIO
SPI
master
Lee Young-jeon of the Korea Research Institute
of Bioscience & Biotechnology.
This innovative technology enables realtime
recording of brain neural signals generated
by the instinctive behaviors of primates,
utilizing wireless power transmission
and communication without the need for
batteries. The research team implanted the
wireless brain neural recorder into the
brain of a non-human primate - specifically,
an experimental monkey - and successfully
measured brain neural signals
during natural behaviors, such as eating
food or snacks, while the monkey moved
freely over a one-month period.
Traditional brain neural signal recorders
are limited by their reliance on wired connections,
which constrain experimental
environments, or by the need for reoperation
to replace discharged batteries. However,
Jang's team has developed the world's
first wireless brain neural signal recorder
capable of covertly measuring brain neural
signals without disrupting the natural behaviors
of non-human primates. This recorder
utilizes wireless power transmission
Real-time wireless signal monitoring
Red on
Red on
Ch1
+100uV
0uV
-100uV
Ch3
+100uV
0uV
-100uV
Ch4
Green on
Green on
Power Level
99%
Ch2
Acceleration Value
X-axis
54
Y-axis
74
Z-axis
52
File
Upload
AI modeling for classicication of
natural instinctive behavior
Neurobehavioral signal analysis
Inputs
ACC
Hidden
layer
Outputs
Monkey
phase
Brain
activity
Inactivation
LFP
Activation
Behavioral features
3-axis
acceleration
Neural
activity
Local field
potential
A diagram of a completely embedded wireless cranial neural signal recorder. (Credit: DGIST)
30
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Medical Design Briefs - January 2025

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