Medical Design Briefs - January 2025 - 31

and communication without the need for
both batteries and wired connections.
The newly developed brain neural signal
recorder is part of the brain engineering
platform technology that enables
the study of instinctive behaviors in
primates. It facilitates the analysis of the
relationship between brain activity and
behavior in human-like non-human primates.
Notably, the system includes
three-dimensional porous electrodes for
precise neural signal measurement in
deep brain regions, a flexible neural
probe, and a biodegradable insertion
shuttle for safe implantation. This is expected
to make substantial contributions
to the study of brain neural circuits.
This groundbreaking technology has
garnered attention as a pioneering innovation
developed in Korea, positioning it
alongside advancements made by Neuralink
in the United States and the Swiss Federal
Institute of Technology in Lausanne.
While Neuralink demonstrated the ability
to make primates play games using only
their thoughts and the Swiss institute enabled
paraplegic primates to walk, this Korean
technology offers a novel capability:
the recording and control of brain neural
activity in non-human primates.
The technology incorporates wireless
power transmission and communication
to enable continuous neural signal recording
with minimal interference. Additionally,
artificial intelligence-based
neural signal analysis is applied to enhance
its capabilities. This advancement
holds immense potential for preclinical
trials of electronic drug technologies
aimed at treating intractable and degenerative
brain diseases, such as Parkinson's
disease and Alzheimer's disease,
paving the way for future therapeutic
applications.
" We have developed a technology that
can wirelessly measure brain neural signals
in a natural state, allowing nonhuman primates
to remain unaware of the neural signal
recorder implanted in their brains, "
says Jang. " By refining this technology for
universal application in preclinical and
clinical trials, we hope to contribute to the
treatment of various intractable brain diseases,
including Parkinson's disease and
Alzheimer's disease, which continue to
pose significant challenges with current
biomedical engineering technologies. "
This research was jointly conducted by
Prof. Jang Kyung-in's team from DGIST
(PhD student Oh Se-hyuck, and integrated
master's and doctoral student Jekal Janghwan)
and senior researcher Lee Youngjeon's
team at the Korea Research Institute
of Bioscience & Biotechnology (postdoctoral
researcher Won Jin-young). It was
funded by the STEAM Research Project
(Global Convergence Research Support)
and the Nano and Material Technology
Development Project of the Korea Research
Foundation under the Ministry of
Science and ICT. The findings were published
in Nature Biomedical Engineering.
Jang is currently working on commercializing
the brain chip technology
through his
faculty
startup,
Enside,
while pursuing international partnerships
with Harvard University and MIT
to globalize the recorder.
For more information, contact Prof.
Kyung-in Jang, at kijang@dgist.ac.kr. or
visit www.dgist.ac.kr.
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Medical Design Briefs - January 2025

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