Medical Design Briefs - January 2025 - 35

Soft Microelectronics Enable Wearable AI for Digital Health
University of Hong Kong, Hong Kong
L
everaging rapid technological advances
for human health is a global
trend, driving the rise of biomedical
engineering research. A fast-rising
field is wearable biosensors, which
have the potential to realize digital
healthcare and artificial intelligence
(AI) in medicine.
Developing edge-computing and AI capabilities
from wearable sensors enhances
their intelligence - critical for the AI of
Things - and reduces power consumption
by minimizing data exchange between
sensory terminals and computing
units. This enables wearable devices to
process data locally, offering real-time processing,
faster feedback, and decreased reliance
on network connectivity and external
devices, thereby enhancing efficiency,
Wireless
communication
Readout
Intrinsically stretchable
OECT arrays
Electrophysiological
signal
Multichannel printing
In-sensor computing
ab
Input
Physical Reservoir
(OECT array)
Output
c
Wearable system
presynapse
MCU
Current
Monitor
Module
Front side Back side
MCU
postsynapse
Neuromorphic hardware
The wearable in-sensor computing platform for health monitoring.
Medical Design Briefs, January 2025
www.medicaldesignbriefs.com
BLE
10 mm
1 HKD coin
Potential
Output
Control
Module
Coin-sized
readout unit
privacy, and responsiveness in applications
like health monitoring, activity tracking,
and smart wearable technology.
However, current sensors lack computing
capabilities and their mechanical
mismatch with soft tissues leads to motion
artifacts, restricting their practical
wearable applications.
To address this issue, a research team
led by Prof. Shiming Zhang of the department
of electrical and electronic
engineering at the University of Hong
Kong (HKU) has introduced a groundbreaking
wearable in-sensor computing
platform. This platform is built on an
emerging microelectronic device, an
organic electrochemical transistor
(OECT), invented explicitly for bioelectronics
applications. The team estabWISE
edge-computing system
lished a standardized materials and fabrication
protocol to endow OECTs with
stretchability. Through these efforts,
the final microelectronics platform integrates
sensing, computing, and
stretchability into one hardware entity,
making it ideal for wearable in-sensor
computing applications.
The research team further developed
an accessible, multichannel printing
platform to ease the fabrication of the
sensors at scale. Through integration
with circuits, they demonstrated the platform's
ability to measure human electrophysiological
signals in real time. Results
showed stable, low-power in-situ computing
even during motion.
The work has recently been published
in Nature Electronics.1
35

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Medical Design Briefs - January 2025

Table of Contents for the Digital Edition of Medical Design Briefs - January 2025

Medical Design Briefs - January 2025 - CV1a
Medical Design Briefs - January 2025 - CV1b
Medical Design Briefs - January 2025 - COV1
Medical Design Briefs - January 2025 - COV2
Medical Design Briefs - January 2025 - 1
Medical Design Briefs - January 2025 - 2
Medical Design Briefs - January 2025 - 3
Medical Design Briefs - January 2025 - 4
Medical Design Briefs - January 2025 - 5
Medical Design Briefs - January 2025 - 6
Medical Design Briefs - January 2025 - 7
Medical Design Briefs - January 2025 - 8
Medical Design Briefs - January 2025 - 9
Medical Design Briefs - January 2025 - 10
Medical Design Briefs - January 2025 - 11
Medical Design Briefs - January 2025 - 12
Medical Design Briefs - January 2025 - 13
Medical Design Briefs - January 2025 - 14
Medical Design Briefs - January 2025 - 15
Medical Design Briefs - January 2025 - 16
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Medical Design Briefs - January 2025 - 18
Medical Design Briefs - January 2025 - 19
Medical Design Briefs - January 2025 - 20
Medical Design Briefs - January 2025 - 21
Medical Design Briefs - January 2025 - 22
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Medical Design Briefs - January 2025 - 28
Medical Design Briefs - January 2025 - 29
Medical Design Briefs - January 2025 - 30
Medical Design Briefs - January 2025 - 31
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Medical Design Briefs - January 2025 - 33
Medical Design Briefs - January 2025 - 34
Medical Design Briefs - January 2025 - 35
Medical Design Briefs - January 2025 - 36
Medical Design Briefs - January 2025 - COV3
Medical Design Briefs - January 2025 - COV4
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