Formulating Beverages for Brain Health - Kyowa March 2020 - 5

Cognizin® Citicoline FAQS
What is citicoline?
Citicoline is a naturally occurring nutrient
found in the brain.
What does it do?
Citicoline increases an important substance
in the brain called phosphatidylcholine that
is critical for healthy brain function.
What is Cognizin®?
Cognizin® is a clinically tested form of
citicoline that can supply the brain with the
nutrition it needs to stay sharp.
How does Cognizin® work?
This patented, branded form of citicoline
is unlike artificial stimulants that ramp up
energy and attention levels only to have
those levels come crashing down later.
Cognizin® provides nutritional support that
helps fuel mental processes and enhance
focus and concentration.

1. Silveri MM et al. Citicoline
enhances frontal lobe bioenergetics
as measured by phosphorus
magnetic resonance spectroscopy.
NMR Biomed. 2008; 21(10):1066-75.

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Has Cognizin® been clinically studied?
Cognizin® Citicoline has been the subject
of several human clinical trials. Two recent
placebo-controlled trials demonstrated
notable benefits of Cognizin® in healthy
adults and adolescents2,3. A study published
in Food and Nutrition Sciences in 2012
concluded that Cognizin® was effective
at improving cognitive inhibition and
attentional performance in healthy adult
women2. Furthermore, the adolescence study
published in Journal of Attention Disorders
demonstrated significant improvements
in motor speed and attention in healthy
adolescent males taking Cognizin®3.
Can it be used in beverage formulating?
Cognizin® achieved self-affirmed GRAS status
in 2009 and is considered safe for food and
beverage applications. It is a pure ingredient
produced by an innovative fermentation
process. Neutral in taste, it is water soluble,
stable to heat, vegetarian and an allergenfree ingredient that is certified kosher.

2. McGlade E. et al. Improved
Attentional Performance Following
Citicoline Administration in Healthy
Adult Women. Food and Nutrition
Sciences. 2012;3:769-773.

3. Yurgelun-Todd D et al. The Effect
of Citicoline Supplementation
on Motor Speed and Attention
in Adolescent Males. Journal of
Attention Disorders. 2015; 1557-1246.

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Formulating Beverages for Brain Health - Kyowa March 2020

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