UEG Journal Abstracts 2023 - 78
Outcome, %b, c
Week
Clinical responsea
Clinical remissiond
PRO-2 remissione
Endoscopic responsef
16 / 20 / 24
28 / 32 / 36
40 / 44
48
48
48
48
Combined Guselkumab
(N=63)
36.5 / 47.6 / 46.0
47.6 / 54.0 / 50.8
54.0 / 52.4
58.7
41.3
42.9
31.7
Endoscopic Score for Crohn's Disease; SF=stool frequency.
a
b
Ustekinumab
(N=21)
42.9 / 52.4 / 52.4
42.9 / 47.6 / 57.1
52.4 / 47.6
47.6
33.3
23.8
23.8
AP=abdominal pain; CD=Crohn's disease; CDAI=Crohn's disease activity index; PRO2=Patient-reported
CDAI components of abdominal pain and stool frequency; SES-CD=Simple
Clinical response was defined as ≥100-point reduction from baseline in CDAI or CDAI <150.
Patients who had a prohibited change in concomitant CD medication, a CD-related surgery, or
discontinued study agent due to lack of efficacy, or an adverse event of worsening CD prior to
the designated analysis timepoint, were considered not to have achieved the endpoint.
c
analysis timepoint were considered not to have achieved the endpoint.
d
e
Patients who had insufficient data to calculate the outcome measure at the designated
Clinical remission was defined as a CDAI <150.
PRO-2 remission was defined as unweighted CDAI component of average daily AP pain score
≤1 and the unweighted CDAI component of average daily SF ≤3, and no worsening of AP or
SF from baseline.
f
Endoscopic response was defined as ≥50% improvement from baseline in SES-CD or SESCD
≤2.
Table. Efficacy Outcomes Among Patients Not in Clinical Responsea
Week 12.
at
References: 1. Panés J, et al. UEG Journal 2022; 10 (Suppl 8).
Disclosure: RP reports consulting fees, speaker fees, or research support
from Abbott, AbbVie, Abbivax, Alimentiv (formerly Robarts), Amgen, Arena
Pharmaceuticals, AstraZeneca, Biogen, Boehringer Ingelheim, Bristol
Myers Squibb, Celgene, Celltrion, Cosmos Pharmaceuticals, Eisai, Elan,
Eli Lilly, Ferring, Galapagos, Fresenius Kabi, Genentech, Gilead Sciences,
Glaxo-Smith Kline, JAMP Bio, Janssen, Merck, Mylan, Novartis, Oppilan
Pharma, Organon, Pandion Pharma, Pendopharm, Pfizer, Progenity, Prometheus
Biosciences, Protagonist Therapeutics, Roche, Sandoz, Satisfai
Health, Shire, Sublimity Therapeutics, Takeda Pharmaceuticals, Theravance
Biopharma, Trellus, Viatris, Ventyx, and UCB.
AA reports consulting fees from AbbVie, Takeda, Janssen, Bristol Myers
Squibb/Celgene, Pfizer, Eli Lilly, Gilead, DiaSorin, and TLL Pharmaceuticals;
reports speaker fees from Abbvie, Takeda, Janssen, Bristol Myers
Squibb, and Pfizer; has served on advisory boards for Abbvie, Takeda,
Janssen, Bristol Myers Squibb, Pfizer, Eli Lilly, and Gilead; has received
research/education support from AbbVie, Janssen, Pfizer, Bristol Myers
Squibb, and Takeda; and is the co-founder of IBD Horizons.
GRDH served as advisor for Abbvie, Ablynx, Amakem, Amgen, AM Pharma,
Avaxia, Biogen, Bristol Myers Squibb, Boehringer Ingelheim, Celgene/Receptos,
Celltrion, Cosmo, Covidien/Medtronics, Ferring, DrFALK Pharma,
Eli Lilly, Engene, Galapagos, Genentech/Roche, Gilead, Glaxo-Smith Kline,
Immunic, Johnson and Johnson, Lycera, Medimetrics, Millenium/Takeda,
Mitsubishi Pharma, Merck Sharp Dome, Mundipharma, Nextbiotics, Novonordisk,
Otsuka, Pfizer/Hospira, Prometheus laboratories/Nestle, Protagonist,
Robarts Clinical Trials, Salix, Samsung Bioepis, Sandoz, Setpoint,
Shire, Teva, Tigenix, Tillotts, Topivert, Versant, and Vifor; and has received
speaker fees from Abbvie, Biogen, Ferring, Johnson and Johnson, Merck
Sharp Dome, Mundipharma, Norgine, Pfizer, Samsung Bioepis, Shire, Millenium/Takeda,
Tillotts, and Vifor.
LS, NAT, AS, MEF, and ZY are employees of Janssen Research & Development,
LLC and own stock/stock options.
EZ reports receiving research support and consulting fees from Janssen,
AbbVie, Takeda, Neopharm, Celgene, and Pfizer.
SD reports receiving consulting fees from Allergan, Amgen, AstraZeneca,
Biogen, Boehringer Ingelheim, Celgene, Celltrion Healthcare, Ferring, Gilead
Sciences, Hospira, Inc., Janssen Research & Development, LLC, Johnson
& Johnson Health Care Systems, Inc., Pfizer, Sandoz, UCB, and Vifor
International Inc.
78
OP080
EXTENDED INDUCTION RESPONSE IN PATIENTS TREATED WITH
MIRIKIZUMAB WITH MODERATELY TO SEVERELY ACTIVE ULCERATIVE
COLITIS IN THE LUCENT TRIALS
G.R. D'Haens1, P.D.R. Higgins2, L. Peyrin-Biroulet3
S.D. Lee5, R. Moses6, I. Redondo7
, R. Escobar8
T. Kobayashi9
1
2
, N. Morris6
, B.E. Sands4
,
University of Michigan, Dept. of Internal Medicine, Ann Arbor,
United States, 3
,
Amsterdam University Medical Centers, Amsterdam, Netherlands,
University Hospital of Nancy, Inserm U 1256 - Team
2 " Inflammation/Cellular Stress and Exposure to Environmental
Risks " , Vandoeuvre-les-Nancy, France, 4
at Mount Sinai, Division Of Gastroenterology, New York, United
States, 5
Center, Seattle, United States, 6
United States, 7
Alcobendas, Spain, 9
Minato-ku, Japan
Eli Lilly Portugal, Lisbon, Portugal, 8
Icahn School of Medicine
University of Washington Medical Center, Digestive Health
Eli Lilly and Company, Indianapolis,
Lilly S.A.,
Kitasato University Kitasato Institute Hospital,
Contact E-Mail Address: peyrinbiroulet@gmail.com
Introduction: The efficacy and safety of mirikizumab (miri) for moderately
to severely active ulcerative colitis (UC) was demonstrated in the Phase 3
LUCENT trials (LUCENT-1 and -2; NCT03518086, NCT03524092). 1,2 Some
patients may improve more slowly and require a prolonged course of induction
before achieving clinical response.
Therefore, we evaluated clinical response in patients who had not responded
by the end of the 12-week(W) induction period and who received
extended induction treatment for an additional 12W.
Aims & Methods: Patients not responding to intravenous (IV) administration
of 300 mg miri every 4 weeks (Q4W) (n=272) at W12 (LUCENT-1),
received extended 12-W induction treatment of open label 300 mg miri
IV Q4W for 3 additional doses (LUCENT-2). Patients responding at W24
(n=144) of continuous IV treatment, entered open label maintenance and
received 200 mg miri Q4W subcutaneously (SC) until W52. Key outcomes
through 52W are reported (Definitions in Table).
Results: Among the 272 patients who failed to achieve a clinical response
after 12W of induction treatment, 72.4% had a Mayo endoscopic subscore
of 3, indicating severe disease. Of these patients, 146 (53.7%) achieved a
clinical response and 31 (11.4%) achieved clinical remission at W24.
Of the 144 responders at 24W entering the open label maintenance study,
52 (36.1%) patients achieved clinical remission, 104 (72.2%) achieved clinical
response, 62 (43.1%) achieved endoscopic remission and 60 (41.7%)
patients achieved histologic improvement at W52.
Furthermore, for these patients, there was a 3.8 (±2.7) point reduction
from baseline in bowel urgency (BU) severity and 58.8% achieved clinically
meaningful improvement in BU (defined as change from baseline in
UEG Journal | Abstract Book
TH has performed joint research with Alfresa Pharma Co. Ltd., and EA
Pharma Co. Ltd.; has received grant support from Mitsubishi Tanabe
Pharma Corporation, EA Pharma Co. Ltd., AbbVie GK, JIMRO Co. Ltd., Zeria
Pharmaceutical Co. Ltd., Daiichi-Sankyo, Kyorin Pharmaceutical Co. Ltd.,
Nippon Kayaku Co. Ltd., Takeda Pharmaceutical Co. Ltd., Pfizer Inc., Mochida
Pharmaceutical Co. Ltd., and JIMRO Co. Ltd; has received consulting
fees from EA Pharma Co. Ltd., AbbVie GK, Celgene K.K., Janssen Pharmaceutical
K.K., Pfizer Inc., and Nichi-Iko Pharmaceutical Co., Ltd; and has
received lecture fees from Mitsubishi Tanabe Pharma Corporation, AbbVie
GK, EA pharma Co. Ltd., Kyorin Pharmaceutical Co. Ltd., JIMRO Co., Janssen
Pharmaceutical K.K., Mochida Pharmaceutical Co. Ltd., Takeda Pharmaceutical
Co. Ltd., and Pfizer Inc.
Tuesday, October 17, 2023
Monday, October 16, 2023
Sunday, October 15, 2023
UEG Journal Abstracts 2023
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UEG Journal Abstracts 2023 - 1180
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UEG Journal Abstracts 2023 - 1199
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