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Chapter 1: Burden of Digestive Disorders
Dyspepsia
Burden estimates for dyspepsia are not separately specified within the GBD 2019 database,
however previous systematic reviews on the subject have been published, including a recent
systematic review by Barberio et al.68 investigating the global prevalence of uninvestigated
dyspepsia among adults, according to the Rome criteria.
Table 5 shows the results of the population-based studies identified and extracted by
Barberio et al.,68 conducted in UEG member countries. Amongst these studies prevalence
estimates vary considerably, ranging from 13.9% in Sweden to 37.5% in Russia when Rome I
criteria were used, 2% in Spain to 35.8% in Sweden when Rome II criteria were used, 4% in
France to 40.4% in Portugal when Rome III criteria were used, and finally 1.1% in Turkey to
12.3% in Egypt when Rome IV criteria were used. The many methodological differences
between the studies (such as the method of data collection, the diagnostic criteria used and
how the diagnostic criteria are applied) likely contribute to variation in prevalence estimates,
however it has also been suggested that risk varies between populations, although further
research is needed to identify specific explanations for this.68 69 70 Nonetheless, the results of
these studies suggest dyspepsia is a common disorder.
Table 5. Characteristics of population-based studies investigating the prevalence of
uninvestigated dyspepsia among adults, conducted in UEG member countries
Criteria used to
Study
Agreus et al.
199571
Agreus et al.
200172
Aro et al.
200473
Aro et al.
200974
Mearin et al.
200575
Basaranoglu
et al. 200876
Hillila et al.
200877
Reshetnikov
et al. 200978
Zagari et al.
201079
Le Pluart et al.
201580
Country
Sweden
Sweden
Sweden
Sweden
Sweden
Spain
Turkey
Finland
Russia
Italy
France
White Book 2: Part 1
Method of data collection
Self-completed postal
questionnaire
Self-completed postal
questionnaire
Self-completed postal
questionnaire
Self-completed postal
questionnaire
Self-completed postal
questionnaire
Self-completed paper questionnaire
provided at an appointment
Interview-administered
questionnaire
Self-completed postal
questionnaire
Questionnaire, type not reported
Interview-administered
questionnaire
Self-completed online
questionnaire
define presence of
dyspepsia
Rome I
(approximated)
Rome II
(approximated)
Rome I
(approximated)
Rome II
(approximated)
Rome III
(approximated)
Rome II (defined as
per Rome)
Rome II (defined as
per Rome)
Rome II (defined as
per Rome)
Rome I criteria
(approximated)
Rome II
(approximated)
Rome III (defined as
per Rome)
Sample
size
1154
1156
2122
2122
1001
443
707
3549
1040
1063
35447
Number of
cases
(prevalence %)
160 (13.9)
133 (11.5)
454 (21.4)
760 (35.8)
202 (20.2)
9 (2.0)
67 (9.5)
279 (7.9)
390 (37.5)
156 (15.1)
1409 (4.0)
103

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