WhiteBook2_Part1 - 109

Chapter 1: Burden of Digestive Disorders
Irritable bowel syndrome
Burden estimates for irritable bowel syndrome are not separately specified within the GBD
2019 database, however a number of systematic reviews on the subject have been published,
including a recent systematic review by Oka et al.90 examining the global prevalence of
irritable bowel syndrome among adults, according to Rome III or IV diagnostic criteria.
Table 6 shows the results of the population-based studies identified and extracted by Oka et
al.,90 conducted in UEG member countries. As can be seen, irritable bowel syndrome is a
common disorder. Nonetheless, amongst these studies prevalence estimates vary
considerably, ranging from 0.9% in Turkey to 29.2% in Croatia when Rome III criteria were
used, and 0.4% in Turkey to 7.6% in Egypt when Rome IV criteria were used. The variation in
prevalence estimates that have been observed between studies likely reflect methodological
differences including the diagnostic criteria applied, however several reviews suggest there
may also be real differences by geographic location which warrants further investigation.90 91
92 93 89
Table 6. Characteristics of population-based studies investigating the prevalence of irritable
bowel syndrome among adults, conducted in UEG member countries
Study
Sperber et al.
200794
Ebling et al.
201195
Chirila et al.
201296
Krogsgaard et
al. 201397
Aziz et al.
201498
Rey et al.
201499
Rasmussen et
al. 201581
Zito et al.
201582
Wensaas et
al. 201688
Buscali et al.
2017100
Jones et al.
2019101
Schauer et al.
2019102
Van de Houte
et al. 2019103
Country
Israel
Croatia
Romania
Denmark
UK
Spain
Denmark
Italy
Norway
France
Sweden
Germany
Belgium
White Book 2: Part 1
Method of data collection
Interview-administered
questionnaire
Self-completed postal
questionnaire
Interview-administered
questionnaire
Self-completed online
questionnaire
Interview-administered
questionnaire
Interview-administered
questionnaire
Self-completed online
questionnaire
Questionnaire, type not reported
Self-completed postal
questionnaire
Self-completed online
questionnaire
Interview-administered
questionnaire
Interview-administered
questionnaire
Self-completed online
questionnaire
Criteria used to
define IBS
Rome III
(approximated)
Rome III (defined
as per Rome)
Rome III (defined
as per Rome)
Rome III (defined
as per Rome)
Rome III (defined
as per Rome)
Rome III (defined
as per Rome)
Rome III (defined
as per Rome)
Rome III (defined
as per Rome)
Rome III (defined
as per Rome)
Rome III (defined
as per Rome)
Rome III
(approximated)
Rome III (defined
as per Rome)
Rome IV (defined
as per Rome)
Sample
size
981
703
193
6112
1002
1500
47174
1134
1042
44350
238
4194
1012
Number of cases
(prevalence %)
112 (11.4)
205 (29.2)
37 (19.2)
979 (16.0)
60 (6.0)
125 (8.3)
4939 (10.5)
172 (15.2)
149 (14.3)
2423 (5.5)
31 (13.0)
148 (3.5)
56 (5.5)
105

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