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Chapter 1: Burden of Digestive Disorders
Gallbladder and biliary diseases
For the 44 member countries combined, trends in age-standardised incidence, prevalence
and mortality rates for gallbladder and biliary diseases have generally decreased over time
(Figure 38). From 2000-2019, age-standardised incidence rates decreased by around 6% (808
to 758 per 100,000), age-standardised mortality rates decreased by around 5% (1.6 to 1.5 per
100,000) and age-standardised prevalence rates decreased by around 14% (3074 to 2631 per
100,000). The total number of incident cases, deaths and prevalent cases in the member
countries combined has increased by around 14% (8,480,640 to 9,686,935), 45% (20,029 to
29,097) and 4% (32,395,478 to 33,815,466), respectively, from 2000-2019.
For the member countries combined, prevalence rates generally increase with age but rates
are far higher amongst women of working age compared to men (Figure 39). For both sexes
combined, age-specific prevalence rates have decreased from 2000-2019 for all age groups.
Amongst the member countries in 2019, age-standardised incidence rates range from 274 to
2222 and 45 to 1407 per 100,000 for women and men, respectively (Figure 40). Agestandardised
mortality rates range from 0.4 to 4.5 and 0.4 to 3.3 per 100,000 for women and
men, respectively, and age-standardised prevalence rates range from 1024 to 9303 and 179
to 4423 per 100,000 for women and men, respectively (Figure 41; Figure 42).
Age-standardised DALY rates for both sexes combined range from 33 to 164 per 100,000
among the member countries (Figure 43). Of the 44 countries, 6 (14%) have experienced a
percentage change increase in age-standardised DALY rates from 2000-2019. All member
countries within Central and Eastern Europe, Northern Africa, Southeastern Europe and the
Nordic region have experienced decreases in age-standardised DALY rates from 2000-2019,
whilst most countries within Southern Europe have experienced increases.
Proportions of gallbladder and biliary disease age-standardised DALY rates attributable to
high BMI and smoking range from 34-52% and 3-13% respectively, among the member
countries (Figure 44). Proportions of burden attributable to smoking are generally lower
among member countries within Northern Africa, and some of the highest proportions occur
among countries within Southeastern Europe. Of the 44 countries, 14 (32%) have
experienced increases in the proportion of burden attributable to smoking, whilst all member
countries have experienced increases in the proportion of burden attributable to high BMI
from 2000-2019. All member countries within Southern Europe and the Nordic region have
experienced decreases in the proportion of burden attributable to smoking over time.
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